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Table 1 Unit operations and select parameters

From: Simplified programming and control of automated radiosynthesizers through unit operations

Unit operation Definition Parameter Description
ADD Adds a reagent to a reaction vessel Reagent Reagent to add
Reactor Reactor to which the reagent will be added
Delivery position Choice of two separate delivery positions
EVAPORATE Evaporates the contents of a reaction vessel Reactor Reactor to evaporate
Evaporation temp Temperature to heat to during evaporation (°C)
Evaporation pressure Inert gas pressure to use when evaporating (psi)
Final temp Temperature to cool to after evaporation (°C)
Duration Time to evaporate after reaching temp (s)
Stir speed Rate of stirring during evaporation
TRANSFER Transfers the contents of one reactor to the next (optionally through a purification cartridge) Source reactor Reactor to transfer from
Target reactor Reactor to transfer to
Mode ‘Trap’ to send to waste or ‘Elute’ to send to the next reactor
REACT Seals the reactor and heats Reactor Reactor to heat
Reaction temp Temperature to heat to during reaction (°C)
Reaction position Choice of two separate reaction positions to avoid cross-contamination if multiple sealed reactions are performed in the same vessel
Duration Time to react after reaching temperature (s)
Final temp Temperature to cool to after reaction (°C)
Stir speed Rate of stirring during reaction
PROMPT Pauses the sequence run and prompts the user Message Message to display when prompting the user
INSTALL Moves the reactor to the install position for reaction vessel removal and/or installation and prompts the user Reactor Reactor to move to the install position
Message Message to display when prompting the user
COMMENT User comment Comment User-specified comment for documentation purposes only (no action performed)
TRAPF18 Traps [18F]fluoride on a QMA cartridge Reactor Reactor where the QMA cartridge is located
Cyclotron flag Specifies if the cyclotron or ELIXYS will push the solution
Duration Trap time (s)
Pressure Pressure of inert gas to use when trapping (psi)
ELUTEF18 Uses a reagent to elute [18F]fluoride off a QMA cartridge Reactor Reactor where the QMA cartridge is located
Reagent Reagent with which to elute the contents of the QMA cartridge
Duration Elute time (s)
Pressure Pressure of inert gas to use when eluting (psi)
MIX Mixes the contents of a reactor by stirring Reactor Reactor to mix
Duration Mix time (s)
Stir speed Rate of stirring while mixing
EXTERNALADD Allows the user to externally add a reagent via tubing Reactor Reactor to externally add the reagent
Reagent name Name of the reagent to add
Message Message to display when prompting the user
TRANSFERTOHPLCa Transfers the contents of the reactor to the HPLC injection loop Source reactor Reactor to transfer from
Mobile phase Reagent containing the mobile phase
MEASURERADIATIONa Measures the radiation levels Reactor Reactor to measure
  1. QMA quaternary methylammonium. aThese unit operations are currently under development.