Table 1 Unit operations and select parameters
From: Simplified programming and control of automated radiosynthesizers through unit operations
Unit operation | Definition | Parameter | Description |
|---|---|---|---|
ADD | Adds a reagent to a reaction vessel | Reagent | Reagent to add |
Reactor | Reactor to which the reagent will be added | ||
Delivery position | Choice of two separate delivery positions | ||
EVAPORATE | Evaporates the contents of a reaction vessel | Reactor | Reactor to evaporate |
Evaporation temp | Temperature to heat to during evaporation (°C) | ||
Evaporation pressure | Inert gas pressure to use when evaporating (psi) | ||
Final temp | Temperature to cool to after evaporation (°C) | ||
Duration | Time to evaporate after reaching temp (s) | ||
Stir speed | Rate of stirring during evaporation | ||
TRANSFER | Transfers the contents of one reactor to the next (optionally through a purification cartridge) | Source reactor | Reactor to transfer from |
Target reactor | Reactor to transfer to | ||
Mode | ‘Trap’ to send to waste or ‘Elute’ to send to the next reactor | ||
REACT | Seals the reactor and heats | Reactor | Reactor to heat |
Reaction temp | Temperature to heat to during reaction (°C) | ||
Reaction position | Choice of two separate reaction positions to avoid cross-contamination if multiple sealed reactions are performed in the same vessel | ||
Duration | Time to react after reaching temperature (s) | ||
Final temp | Temperature to cool to after reaction (°C) | ||
Stir speed | Rate of stirring during reaction | ||
PROMPT | Pauses the sequence run and prompts the user | Message | Message to display when prompting the user |
INSTALL | Moves the reactor to the install position for reaction vessel removal and/or installation and prompts the user | Reactor | Reactor to move to the install position |
Message | Message to display when prompting the user | ||
COMMENT | User comment | Comment | User-specified comment for documentation purposes only (no action performed) |
TRAPF18 | Traps [18F]fluoride on a QMA cartridge | Reactor | Reactor where the QMA cartridge is located |
Cyclotron flag | Specifies if the cyclotron or ELIXYS will push the solution | ||
Duration | Trap time (s) | ||
Pressure | Pressure of inert gas to use when trapping (psi) | ||
ELUTEF18 | Uses a reagent to elute [18F]fluoride off a QMA cartridge | Reactor | Reactor where the QMA cartridge is located |
Reagent | Reagent with which to elute the contents of the QMA cartridge | ||
Duration | Elute time (s) | ||
Pressure | Pressure of inert gas to use when eluting (psi) | ||
MIX | Mixes the contents of a reactor by stirring | Reactor | Reactor to mix |
Duration | Mix time (s) | ||
Stir speed | Rate of stirring while mixing | ||
EXTERNALADD | Allows the user to externally add a reagent via tubing | Reactor | Reactor to externally add the reagent |
Reagent name | Name of the reagent to add | ||
Message | Message to display when prompting the user | ||
TRANSFERTOHPLCa | Transfers the contents of the reactor to the HPLC injection loop | Source reactor | Reactor to transfer from |
Mobile phase | Reagent containing the mobile phase | ||
MEASURERADIATIONa | Measures the radiation levels | Reactor | Reactor to measure |