Factors affecting tumor 18 F-FDG uptake in longitudinal mouse PET studies

EJNMMI Research

Table 1 Likelihood ratio test on analysis methods and model selection for U87

Response variable	Model ^a	Log likelihood		Random parameters	D ^d	P ^d	AIC _c	RSS
Response variable	Model ^a	Standard ^c	Mixed ^c	Random parameters	D ^d	P ^d	AIC _c	RSS
K _i/RC	1	54.81	54.81	a	1.4 × 10⁻⁸	>0.99	−105.41	4.88 × 10⁻³
	2	55.00	54.82	a, c	0.368	0.947	−102.92	4.87 × 10⁻³
	3^b	55.91	55.91	a	1.03 × 10⁻⁸	>0.99	−107.12	4.36 × 10⁻³
	4^b	56.14	56.14	a	1.03 × 10⁻⁸	>0.99	−102.78	4.27 × 10⁻³
SUV/RC	1	−15.45	−15.45	a	4.3 × 10⁻⁹	>0.99	35.12	5.49
	2	−15.29	−14.53	a, c	1.53	0.675	37.29	5.41
	3^b	−13.10	−13.04	a	0.102	0.75	30.41	4.34
	4^b	−13.07	−13.04	a	0.0606	0.81	32.85	4.33

^aModels 1 to 4 correspond to Equations 6 to 9. ^bThese models were built with b set to 0. ^cStandard denotes the standard least-squares method, and mixed denotes the mixed-effects method. ^d D is the likelihood ratio statistic, and P is the significance level.