Arg302Gln PRKAG2 increases LV volume and reduces cardiac function. Representative echocardiography M-mode images (A) of a TGwt and TGmut mouse. Using B-mode echocardiography measurements of the long axis, comparison of LV volume (B), fractional shortening (C), and wall thickness (D). TGwt n = 4 and TGmut n = 4. *p < 0.05, Student's t test.