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EJNMMI Research
Figure 1 | EJNMMI Research

Figure 1

From: 11C-LY2428703, a positron emission tomographic radioligand for the metabotropic glutamate receptor 1, is unsuitable for imaging in monkey and human brains

Figure 1

Transverse brain slices from a healthy volunteer at the level of the cerebellum (left) and frontal cortex (right). Images are the sum of all PET frames coregistered to the individual MRI. The foci of high 11C-LY2428703 uptake were due to vascular activity (carotids and posterior venous sinuses) at early time points. Vascular activity was clearly visible on the final summed image because uptake in the brain regions was negligible.

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