Table 1 Population description and performance at neuropsychological assessment
From: Cortical florbetapir-PET amyloid load in prodromal Alzheimer’s disease patients
Prodromal patients | Control subjects | p value | |
|---|---|---|---|
n | 22 | 17 | NA |
Age | 72.4 ± 5.0 | 69.9 ± 4.8 | .110 |
Gender | 12 M/10 F | 7 M/10 F | .408 |
Level of education | 11.3 ± 2.7 | 12.8 ± 3.3 | .163 |
Disease duration | 3.8 ± 3.6 | NA | NA |
ApoE genotype | 2 E4/E4 | NA | NA |
9 E3/E4 | |||
5 E3/E3 | |||
3 E2/E3 | |||
Daily-life autonomy | |||
CDR scale | 0.5 ± 0.0 | 0.0 ± 0.0 | <.001* |
Anterograde verbal memory | |||
FCSRT sum of free recalls (/48) | 11.6 ± 5.9 | 32.2 ± 4.6 | <.001* |
FCSRT sum of free + cued recalls (/48) | 28.7 ± 11.9 | 46.6 ± 1.9 | <.001* |
Global cognitive state | |||
MMSE | 25.7 ± 1.4 | 28.4 ± 0.7 | <.001* |
Depression scale | |||
Beck (/39) | 3.0 ± 2.6 | 2.7 ± 2.6 | .666 |
Anxiety scale | |||
Y-A (/80) | 34.3 ± 8.9 | 3.2 ± 6.0 | .830 |
Anterograde visual memory | |||
DMS48 set 1 (/48) | 41.0 ± 6.0 | 46.5 ± 2.0 | .003* |
DMS48 set 2 (/48) | 40.0 ± 7.0 | 45.9 ± 2.2 | .014* |
Rey complex figure memory (/36) | 9.2 ± 6.6 | 19.4 ± 6.1 | .002* |
Semantic memory | |||
Information subtest (WAIS) (/28) | 13.8 ± 5.5 | 20.1 ± 6.2 | .014* |
TOP 12 faces version: global score (/96) | 74.8 ± 6.7 | 84.6 ± 6.0 | .003* |
TOP 12 faces version: naming (/12) | 5.2 ± 3.4 | 9.3 ± 2.2 | .006* |
Short-term memory | |||
WAIS-III digit span: forward | 5.6 ± 1.4 | 5.4 ± 1.0 | 1.763 |
Working memory | |||
WAIS-III digit span: backward | 4.0 ± 1.2 | 4.6 ± 0.9 | .514 |
Language | |||
DO80 (/80) | 78.1 ± 3.8 | 79.4 ± 1.2 | .549 |
Praxies | |||
Rey complex figure copy (/36) | 34.4 ± 1.9 | 34.6 ± 2.0 | 1.258 |
Speed processing | |||
Digit-symbol test (/90) | 34.1 ± 12.6 | 52.8 ± 10.2 | <.001* |
Executive functions | |||
Phonemic verbal fluency: letter (P) | 19.6 ± 8.1 | 22.6 ± 6.1 | .674 |
Semantic verbal fluency: ‘animal’ category | 21.7 ± 7.3 | 31.8 ± 7.4 | .012* |
TMT B time | 170.3 ± 85.3 | 94.1 ± 38.4 | .014* |
Interference time on the Stroop test | 108.1 ± 45.1 | 51.6 ± 31.9 | .002* |
FAB (/18) | 15.1 ± 2.5 | 17.1 ± 0.8 | .098 |
Gnosia | |||
Benton Facial Recognition (/58) | 46.0 ± 3.3 | 48.1 ± 3.5 | .476 |