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Table 2 Biodistribution of [ 18 F]-(3), [ 11 C]-(4), [ 18 F]-(5), and [ 11 C]-(6) in normal NMRI mice

From: Preclinical evaluation of carbon-11 and fluorine-18 sulfonamide derivatives for in vivo radiolabeling of erythrocytes

Organs [ 18F]-(3) [ 11C]-(4) [ 18F]-(5) [ 11C]-(6)
2 min 60 min 2 min 60 min 2 min 60 min 2 min 60 min
Percentage of ID Urine 0.2 ± 0.1 15.9 ± 6.0 0.4 ± 0.1 4.4 ± 2.7 0.3 ± 0.1 10.0 ± 5.0 0.3 ± 0.1 4.8 ± 0.3
Kidneys 10.6 ± 0.8 2.8 ± 0.1 8.1 ± 1.3 4.1 ± 0.3 4.1 ± 0.8 3.7 ± 1.1 3.7 ± 0.1 4.1 ± 0.6
Liver 15.8 ± 1.5 8.3 ± 1.2 8.4 ± 0.7 9.2 ± 1.1 6.0 ± 1.1 4.0 ± 0.2 6.9 ± 0.4 6.1 ± 0.5
Spleen + pancreas 1.3 ± 0.2 0.9 ± 0.3 0.6 ± 0.1 0.8 ± 0.1 1.1 ± 0.1 0.9 ± 0.4 1.2 ± 0.1 2.3 ± 0.6
Lungs 2.3 ± 0.5 0.7 ± 0.3 4.9 ± 2.5 4.2 ± 1.1 7.3 ± 3.9 1.8 ± 0.6 6.3 ± 2.7 3.1 ± 1.4
Heart 0.8 ± 0.0 0.2 ± 0.2 0.5 ± 0.1 0.5 ± 0.1 0.6 ± 0.1 0.6 ± 0.2 0.7 ± 0.2 0.4 ± 0.1
Intestines 5.9 ± 0.8 18.6 ± 1.0 3.6 ± 1.3 12.4 ± 0.8 2.9 ± 0.4 9.6 ± 2.8 5.2 ± 0.9 19.3 ± 1.0
Stomach 0.7 ± 0.1 1.9 ± 1.3 0.7 ± 0.1 2.6 ± 0.3 0.8 ± 0.2 4.2 ± 3.1 1.5 ± 0.3 2.4 ± 0.2
Brain 0.2 ± 0.0 0.2 ± 0.1 0.2 ± 0.0 0.3 ± 0.0 0.3 ± 0.0 1.0 ± 0.1 0.7 ± 0.1 1.5 ± 0.1
Blood 71.0 ± 4.3 31.7 ± 2.1 90.5 ± 5.9 72.5 ± 7.6 106.3 ± 5.2 71.0 ± 14.5 83.4 ± 7.7 49.7 ± 4.8
Carcass 18.10 ± 2.32 31.35 ± 3.67 17.6 ± 1.5 21.2 ± 2.8 18.8 ± 1.6 22.4 ± 1.5 28.4 ± 2.0 26.1 ± 1.0
SUV Kidneys 5.6 ± 0.6 1.6 ± 0.1 4.3 ± 0.7 2.5 ± 0.2 3.1 ± 0.6 2.5 ± 0.4 2.4 ± 0.3 2.4 ± 0.2
Liver 3.2 ± 0.2 1.7 ± 0.3 1.5 ± 0.2 1.9 ± 0.3 1.4 ± 0.3 1.0 ± 0.1 1.5 ± 0.1 1.4 ± 0.2
Spleen 1.6 ± 0.2 1.1 ± 0.3 0.9 ± 0.1 1.1 ± 0.2 2.1 ± 0.7 2.2 ± 0.8 1.9 ± 0.8 2.4 ± 0.4
Lungs 3.5 ± 1.0 1.1 ± 0.4 6.0 ± 1.6 4.7 ± 0.7 9.3 ± 2.9 3.8 ± 0.4 6.2 ± 2.1 3.5 ± 1.1
Heart 2.3 ± 1.3 0.5 ± 0.4 1.2 ± 0.2 1.0 ± 0.3 1.6 ± 0.4 1.7 ± 0.5 1.6 ± 0.4 0.9 ± 0.1
Brain 0.2 ± 0.0 0.1 ± 0.0 0.2 ± 0.0 0.2 ± 0.0 0.5 ± 0.1 1.4 ± 0.2 0.7 ± 0.1 1.1 ± 0.1
  Blood 10.1 ± 0.6 4.5 ± 0.3 12.9 ± 0.8 10.4 ± 1.1 17.3 ± 2.5 11.1 ± 1.2 11.9 ± 1.1 7.1 ± 0.7
  1. This activity is at 2 and 60 min p.i. Data are expressed as mean ± standard error (n = 3).