Skip to main content
EJNMMI Research

Table 2 Biodistribution of [ 18 F]-(3), [ 11 C]-(4), [ 18 F]-(5), and [ 11 C]-(6) in normal NMRI mice

From: Preclinical evaluation of carbon-11 and fluorine-18 sulfonamide derivatives for in vivo radiolabeling of erythrocytes

Organs

[ 18F]-(3)

[ 11C]-(4)

[ 18F]-(5)

[ 11C]-(6)

2 min

60 min

2 min

60 min

2 min

60 min

2 min

60 min

Percentage of ID

Urine

0.2 ± 0.1

15.9 ± 6.0

0.4 ± 0.1

4.4 ± 2.7

0.3 ± 0.1

10.0 ± 5.0

0.3 ± 0.1

4.8 ± 0.3

Kidneys

10.6 ± 0.8

2.8 ± 0.1

8.1 ± 1.3

4.1 ± 0.3

4.1 ± 0.8

3.7 ± 1.1

3.7 ± 0.1

4.1 ± 0.6

Liver

15.8 ± 1.5

8.3 ± 1.2

8.4 ± 0.7

9.2 ± 1.1

6.0 ± 1.1

4.0 ± 0.2

6.9 ± 0.4

6.1 ± 0.5

Spleen + pancreas

1.3 ± 0.2

0.9 ± 0.3

0.6 ± 0.1

0.8 ± 0.1

1.1 ± 0.1

0.9 ± 0.4

1.2 ± 0.1

2.3 ± 0.6

Lungs

2.3 ± 0.5

0.7 ± 0.3

4.9 ± 2.5

4.2 ± 1.1

7.3 ± 3.9

1.8 ± 0.6

6.3 ± 2.7

3.1 ± 1.4

Heart

0.8 ± 0.0

0.2 ± 0.2

0.5 ± 0.1

0.5 ± 0.1

0.6 ± 0.1

0.6 ± 0.2

0.7 ± 0.2

0.4 ± 0.1

Intestines

5.9 ± 0.8

18.6 ± 1.0

3.6 ± 1.3

12.4 ± 0.8

2.9 ± 0.4

9.6 ± 2.8

5.2 ± 0.9

19.3 ± 1.0

Stomach

0.7 ± 0.1

1.9 ± 1.3

0.7 ± 0.1

2.6 ± 0.3

0.8 ± 0.2

4.2 ± 3.1

1.5 ± 0.3

2.4 ± 0.2

Brain

0.2 ± 0.0

0.2 ± 0.1

0.2 ± 0.0

0.3 ± 0.0

0.3 ± 0.0

1.0 ± 0.1

0.7 ± 0.1

1.5 ± 0.1

Blood

71.0 ± 4.3

31.7 ± 2.1

90.5 ± 5.9

72.5 ± 7.6

106.3 ± 5.2

71.0 ± 14.5

83.4 ± 7.7

49.7 ± 4.8

Carcass

18.10 ± 2.32

31.35 ± 3.67

17.6 ± 1.5

21.2 ± 2.8

18.8 ± 1.6

22.4 ± 1.5

28.4 ± 2.0

26.1 ± 1.0

SUV

Kidneys

5.6 ± 0.6

1.6 ± 0.1

4.3 ± 0.7

2.5 ± 0.2

3.1 ± 0.6

2.5 ± 0.4

2.4 ± 0.3

2.4 ± 0.2

Liver

3.2 ± 0.2

1.7 ± 0.3

1.5 ± 0.2

1.9 ± 0.3

1.4 ± 0.3

1.0 ± 0.1

1.5 ± 0.1

1.4 ± 0.2

Spleen

1.6 ± 0.2

1.1 ± 0.3

0.9 ± 0.1

1.1 ± 0.2

2.1 ± 0.7

2.2 ± 0.8

1.9 ± 0.8

2.4 ± 0.4

Lungs

3.5 ± 1.0

1.1 ± 0.4

6.0 ± 1.6

4.7 ± 0.7

9.3 ± 2.9

3.8 ± 0.4

6.2 ± 2.1

3.5 ± 1.1

Heart

2.3 ± 1.3

0.5 ± 0.4

1.2 ± 0.2

1.0 ± 0.3

1.6 ± 0.4

1.7 ± 0.5

1.6 ± 0.4

0.9 ± 0.1

Brain

0.2 ± 0.0

0.1 ± 0.0

0.2 ± 0.0

0.2 ± 0.0

0.5 ± 0.1

1.4 ± 0.2

0.7 ± 0.1

1.1 ± 0.1

 

Blood

10.1 ± 0.6

4.5 ± 0.3

12.9 ± 0.8

10.4 ± 1.1

17.3 ± 2.5

11.1 ± 1.2

11.9 ± 1.1

7.1 ± 0.7

  1. This activity is at 2 and 60 min p.i. Data are expressed as mean ± standard error (n = 3).
Back to article page