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EJNMMI Research
Figure 2 | EJNMMI Research

Figure 2

From: Radiosynthesis and preclinical evaluation of [11C]prucalopride as a potential agonist PET ligand for the 5-HT4 receptor

Figure 2

Representative HPLC chromatograms of the purification of the reaction mixture and formulated [11 C]prucalopride. (A) Chromatograms of the semi-preparative HPLC purification of the reaction mixture. (A1) UV vs. time; (A2) radioactivity vs. time. Retention times were 8 min for the precursor and 11 min for [11C]prucalopride. (B) Analytical HPLC chromatograms of formulated [11C]prucalopride vs. time. (B1) UV vs. time; (B2) radioactivity vs. time; (B3) UV spiked with cold prucalopride. Retention times were 8.5, 8.8 and 8.5 min for UV, radioactivity signal of [11C]prucalopride and UV spiked with cold prucalopride, respectively. UV and radioactivity detections were connected in series, giving a time delay of 0.3 min.

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