Figure 6
From: 111In-BnDTPA-F3: an Auger electron-emitting radiotherapeutic agent that targets nucleolin
In vivo xenograft growth inhibition by 111 In-BnDTPA-F3. Mice, bearing 231-H2N xenografts, were injected intravenously with PBS, BnDTPA-F3, or 111In-BnDTPA-F3. Tumor size was measured twice weekly by a caliper. (A) Normalized tumor volume. (B) Growth rate (K) in mm3 per day. Results are expressed as average growth rates of tumors in seven mice ± SEM. **p = 0.0031. (C) Kaplan-Meier survival curves generated using the time tumors reached twice the size at the beginning of the study (V =2V 0). (D) Kaplan-Meier survival curves. Mice were killed when the tumor reached its maximally allowed volume (V =V max).