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EJNMMI Research

Table 1 Overview of the number of animals and procedures used in each experiment

From: PET imaging of brain inflammation during early epileptogenesis in a rat model of temporal lobe epilepsy

 

[ 18F]-PBR111 metabolism post-mortem evaluation a (in vitro [ 18F]-PBR111 b)

Ex vivo [ 18F]-PBR111 c

In vivo [ 18F]-PBR111 PET and post-mortem evaluation d

Control (n)

4 (1)

1

4

Minor SE (n)

3 (0)

0

0

Medium SE (n)

3 (1)

1

2

Severe SE (n)

0 (0)

1

3

  1. a Post-mortem evaluation was performed on sagittal sections and included in vitro [125I]-CLINDE autoradiography and OX-42 immunohistochemistry for all animals; b in vitro [18F]-PBR111 in two representative animals; c ex vivo [18F]-PBR111 binding was measured in sagittal sections; d post-mortem evaluation was performed on coronal sections in these animals and included in vitro [125I]-CLINDE autoradiography, OX-42 immunohistochemistry and Cresyl Echt Violet staining.
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