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EJNMMI Research
Figure 2 | EJNMMI Research

Figure 2

From: Pharmacokinetic modeling of P-glycoprotein function at the rat and human blood–brain barriers studied with (R)-[11C]verapamil positron emission tomography

Figure 2

The final population model. V c, V p1 and V p2 are the pharmacological volumes of distribution in central and two peripheral plasma compartments, while V br1 and V br2 are the volumes of distribution in central and peripheral brain compartments, respectively. CL, Q 1, Q 2, Q in, Q out, and Q br are total body clearance, bidirectional clearance between plasma and peripheral compartment 1, bidirectional clearance between plasma and peripheral compartment 2, clearance into the brain, clearance out of the brain, and bidirectional clearance between central and peripheral brain compartments, respectively. Plus sign (+) indicates an increase in V br1 due to rat group (EffSE) and the effect of tariquidar (Efftariquidar), resulting in a decrease in Q out. Asterisk (*) indicates the parameter estimates, which were fixed during modeling procedure, though V br2 was only fixed in rats.

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