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Table 2 Biodistribution of radioactivity after concomitant intravenous injection of (+)-[ 125 I]IV-OH and (+)-[ 131 I] p IV in tumor-bearing mice

From: Development and evaluation of a novel radioiodinated vesamicol analog as a sigma receptor imaging agent

Analog

Tissue

Time of post-injection

  

10 min

1 h

3 h

24 h

(+)-[125I] IV-OH

Blood

1.28 (0.13)*

1.04 (0.10)*

0.43 (0.09)**

0.00 (0.00)*

 

Tumor

9.55 (0.64)**

5.45 (0.70)

2.57 (0.41)

0.06 (0.04)**

 

Liver

7.82 (0.32)*

9.80 (0.94)**

2.81 (0.33)*

0.06 (0.03)*

 

Kidney

35.01 (2.83)*

15.30 (1.80)

4.89 (0.87)**

0.04 (0.01)*

 

Intestine

5.26 (0.61)*

7.96 (0.72)*

4.84 (0.95)

0.14 (0.02)*

 

Spleen

8.11 (1.24)

1.84 (0.11)*

0.60 (0.12)*

0.01 (0.02)*

 

Pancreas

25.04 (2.40)*

12.80 (0.97)*

2.94 (0.49)*

0.01 (0.01)*

 

Lung

9.74 (1.59)*

1.85 (0.18)*

0.63 (0.11)*

0.01 (0.02)*

 

Heart

3.57 (0.40)*

0.78 (0.05)*

0.27(0.00)**

0.01 (0.01)*

 

Stomacha

1.18 (0.36)

0.62 (0.18)

0.55 (0.25)

0.03 (0.02)*

 

Brain

5.14 (0.50)*

1.04 (0.08)*

0.22 (0.02)*

0.00 (0.00)*

 

Muscle

2.20 (0.58)

0.45 (0.03)*

0.26 (0.10)

0.01 (0.01)*

(+)-[131I]p IV

Blood

0.45 (0.03)

0.28 (0.02)

0.17 (0.01)

0.50 (0.01)

 

Tumor

7.20 (0.40)

5.79 (0.37)

6.46 (3.42)

6.81 (2.60)

 

Liver

9.83 (0.39)

13.31 (1.25)

13.05 (0.46)

10.28 (0.59)

 

Kidney

18.47 (1.59)

11.72 (1.90)

7.37 (0.89)

6.15 (0.30)

 

Intestine

4.31 (0.78)

5.14 (0.12)

3.20 (0.13)

2.59 (0.24)

 

Spleen

8.12 (1.09)

8.99 (1.00)

4.04 (0.30)

2.52 (0.23)

 

Pancreas

16.58 (1.82)

21.94 (2.50)

27.35 (0.24)

27.36 (0.70)

 

Lung

26.10 (3.39)

13.13 (3.28)

6.59 (0.56)

3.01 (0.46)

 

Heart

8.66 (0.81)

5.55 (0.70)

2.11 (0.37)

0.96 (0.07)

 

Stomacha

1.07 (0.32)

0.73 (0.26)

0.62 (0.19)

0.49 (0.06)

 

Brain

6.02 (0.74)

6.47 (0.73)

4.12 (0.30)

2.22 (0.10)

 

Muscle

2.03 (0.53)

1.62 (0.22)

0.72 (0.29)

0.42 (0.03)

  1. Data are expressed as percent injected dose per gram tissue. Each value represents the mean (SD) for three or four animals. aData are expressed as percent injected dose. Significance was determined using paired Student's t test (*p < 0.01 vs. (+)-[131I]p IV, **p < 0.05).