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Table 2 Biodistribution of radioactivity after concomitant intravenous injection of (+)-[ 125 I]IV-OH and (+)-[ 131 I] p IV in tumor-bearing mice

From: Development and evaluation of a novel radioiodinated vesamicol analog as a sigma receptor imaging agent

Analog Tissue Time of post-injection
   10 min 1 h 3 h 24 h
(+)-[125I] IV-OH Blood 1.28 (0.13)* 1.04 (0.10)* 0.43 (0.09)** 0.00 (0.00)*
  Tumor 9.55 (0.64)** 5.45 (0.70) 2.57 (0.41) 0.06 (0.04)**
  Liver 7.82 (0.32)* 9.80 (0.94)** 2.81 (0.33)* 0.06 (0.03)*
  Kidney 35.01 (2.83)* 15.30 (1.80) 4.89 (0.87)** 0.04 (0.01)*
  Intestine 5.26 (0.61)* 7.96 (0.72)* 4.84 (0.95) 0.14 (0.02)*
  Spleen 8.11 (1.24) 1.84 (0.11)* 0.60 (0.12)* 0.01 (0.02)*
  Pancreas 25.04 (2.40)* 12.80 (0.97)* 2.94 (0.49)* 0.01 (0.01)*
  Lung 9.74 (1.59)* 1.85 (0.18)* 0.63 (0.11)* 0.01 (0.02)*
  Heart 3.57 (0.40)* 0.78 (0.05)* 0.27(0.00)** 0.01 (0.01)*
  Stomacha 1.18 (0.36) 0.62 (0.18) 0.55 (0.25) 0.03 (0.02)*
  Brain 5.14 (0.50)* 1.04 (0.08)* 0.22 (0.02)* 0.00 (0.00)*
  Muscle 2.20 (0.58) 0.45 (0.03)* 0.26 (0.10) 0.01 (0.01)*
(+)-[131I]p IV Blood 0.45 (0.03) 0.28 (0.02) 0.17 (0.01) 0.50 (0.01)
  Tumor 7.20 (0.40) 5.79 (0.37) 6.46 (3.42) 6.81 (2.60)
  Liver 9.83 (0.39) 13.31 (1.25) 13.05 (0.46) 10.28 (0.59)
  Kidney 18.47 (1.59) 11.72 (1.90) 7.37 (0.89) 6.15 (0.30)
  Intestine 4.31 (0.78) 5.14 (0.12) 3.20 (0.13) 2.59 (0.24)
  Spleen 8.12 (1.09) 8.99 (1.00) 4.04 (0.30) 2.52 (0.23)
  Pancreas 16.58 (1.82) 21.94 (2.50) 27.35 (0.24) 27.36 (0.70)
  Lung 26.10 (3.39) 13.13 (3.28) 6.59 (0.56) 3.01 (0.46)
  Heart 8.66 (0.81) 5.55 (0.70) 2.11 (0.37) 0.96 (0.07)
  Stomacha 1.07 (0.32) 0.73 (0.26) 0.62 (0.19) 0.49 (0.06)
  Brain 6.02 (0.74) 6.47 (0.73) 4.12 (0.30) 2.22 (0.10)
  Muscle 2.03 (0.53) 1.62 (0.22) 0.72 (0.29) 0.42 (0.03)
  1. Data are expressed as percent injected dose per gram tissue. Each value represents the mean (SD) for three or four animals. aData are expressed as percent injected dose. Significance was determined using paired Student's t test (*p < 0.01 vs. (+)-[131I]p IV, **p < 0.05).