Estimation of absorbed dose to the kidneys in patients after treatment with 177Lu-octreotate: comparison between methods based on planar scintigraphy

Larsson, Maria; Bernhardt, Peter; Svensson, Johanna B; Wängberg, Bo; Ahlman, Håkan; Forssell-Aronsson, Eva

doi:10.1186/2191-219X-2-49

EJNMMI Research

Table 2 The mean absorbed dose per administered activity

From: Estimation of absorbed dose to the kidneys in patients after treatment with ¹⁷⁷Lu-octreotate: comparison between methods based on planar scintigraphy

Patient number	First treatment cycle	D/A _administered (Gy/GBq)
	Kidney size/mass/AP thickness (cm/kg/cm)			Treatment cycle
		1	2	3	4	5
1	Right (5.5/0.129/27)	0.68	0.87	0.72	0.51	ND
1	Left	NA	NA	NA	NA	ND
2	Right (6.8/0.168/17)	0.38	0.48	0.45	0.37	0.52
2	Left (5.7/0.194/17)	0.43	0.70	0.57	0.52	0.33
3	Right (6.6/0.190/19)	1.09	0.76	0.82	0.84	ND
3	Left (5.27/0.154/19)	0.91	0.68	0.76	0.86	ND
4	Right	NA	NA	NA	NA	ND
4	Left (4.3/0.113/21)	0.86	0.77	0.84	0.95	ND
5	Right	NP	NP	NP	NP	NP
5	Left (6.4/0.234/23)	0.74	0.57	0.76	ND	ND
6	Right (5.4/0.135/23)	0.89	ND	ND	ND	ND
6	Left (5.6/0.137/22)	0.56	ND	ND	ND	ND
7	Right (6.6/0.190/24)	0.60	0.60	0.62	ND	ND
7	Left (5.8/0.161/25)	0.78	0.79	0.69	ND	ND
8	Right (5.5/0.123/22)	0.60	0.60	0.62	1.1	ND
8	Left (5.0/0.152/23)	0.78	0.79	0.69	0.74	ND
9	Right (5.4/0.135/16)	0.96	1.2	ND	ND	ND
9	Left (3.0/0.054/18)	1.7	2.4	ND	ND	ND
10	Right (5.9/0.138/18)	1.2	1.3	ND	ND	ND
10	Left (5.6/0.149/17)	0.91	1.2	ND	ND	ND
11	Right (5.4/0.157/20)	0.77	0.94	0.92	1.1	ND
11	Left (6.3/0.177/20)	0.69	0.73	0.94	0.87	ND
12	Right (6.3/0.137/16)	0.73	0.61	0.59	ND	ND
12	Left (5.8/0.168/17)	0.74	0.68	0.78	ND	ND
13	Right (5.1/0.131/19)	0.59	0.87	0.79	ND	ND
13	Left (5.1/0.107/20)	NA	NA	NA	ND	ND
14	Right (3.7/0.087/18)	NA	NA	NA	ND	ND
14	Left (4.7/0.088/19)	0.94	1.0	0.97	ND	ND
15	Right (5.7/0.159/19)	1.3	ND	ND	ND	ND
15	Left (5.2/0.188/18)	1.3	ND	ND	ND	ND
16	Right (6.5/0.215/25)	0.63	0.59	0.61	0.56	ND
16	Left (6.3/0.231/26)	0.52	0.52	0.47	0.51	ND
17	Right (5.6/0.187/23)	0.50	0.47	0.50	0.63	ND
17	Left (6.4/0.215/24)	0.49	0.52	0.50	0.52	ND
18	Right (5.3/0.132/17)	0.85	0.88	0.94	ND	ND
18	Left (5.2/0.117/19)	1.0	1.1	1.0	ND	ND
19	Right	NA	NA	NA	ND	ND
19	Left (4.5/0.094/21)	1.2	0.97	1.3	ND	ND
20	Right (5.6/0.184/23)	0.66	0.56	0.57	0.57	ND
20	Left (5.6/0.153/23)	0.77	0.67	0.68	0.61	ND
21	Right (5.9/0.091/16)	1.5	1.6	ND	ND	ND
21	Left (4.7/0.098/18)	1.3	1.3	ND	ND	ND
22	Right (5.6/0.162/23)	0.73	0.74	0.73	0.64	ND
22	Left (5.6/0.194/24)	0.74	0.72	0.66	0.60	ND
23	Right	NA	NA	NA	ND	ND
23	Left (4.7/0.124/20)	0.70	0.83	0.84	ND	ND
24	Right	NA	NA	NA	NA	ND
24	Left (5.6/0.167/24)	0.86	0.74	0.80	0.73	ND
25	Right (5.9/0.186/24)	0.55	0.48	0.44	0.46	ND
25	Left (5.9/0.209/26)	0.52	0.47	0.40	0.46	ND
26	Right (7.0/0.189/32)	1.3	1.4	ND	ND	ND
26	Left (5.5/0.145/30)	1.5	1.3	ND	ND	ND
27	Right (5.6/0.156/23)	1.2	1.3	1.2	ND	ND
27	Left (6.1/0.200/22)	0.68	1.2	1.3	ND	ND
28	Right (4.4/0.111/18)	1.0	1.0	ND	ND	ND
28	Left (5.1/0.158/19)	1.1	1.0	ND	ND	ND
29	Right	NA	NA	NA	NA	ND
29	Left (5.6/0.181/21)	0.59	0.67	0.65	0.81	ND
30	Right (6.1/0.192/21)	0.51	0.48	0.43	ND	ND
30	Left	NA	NA	NA	ND	ND
31	Right	NA	NA	ND	ND	ND
31	Left (4.9/0.118/18)	0.58	0.49	ND	ND	ND
32	Right (6.2/0.155/24)	0.95	NA	ND	ND	ND
32	Left (6.4/0.168/24)	0.72	0.75	ND	ND	ND
33	Right (5.3/0.116/23)	1.0	ND	ND	ND	ND
33	Left (5.3/0.161/22)	0.65	ND	ND	ND	ND

NP, not present; NA, not analyzable; ND, not done. The mean absorbed dose per administered activity (Gy/GBq) to the right and left kidneys for each patient given for each treatment cycle (1 to 5 per patient). Patient no. 5 had only one kidney. For patients no. 1, 4, 13, 14, 19, 23, 24, 29, 30, 31, and 32, it was not possible to determine the absorbed dose to one of the kidneys for one or several treatment cycles (see text).

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