Synthesis and evaluation of 2-chloro N-[(S)-{(S)-1-[11 C]methylpiperidin-2-yl} (phenyl)methyl]3-trifluoromethyl-benzamide ([11 C]N-methyl-SSR504734) as a PET radioligand for glycine transporter 1

EJNMMI Research

Table 2 Total distribution volume ( V _T ) in brain regions of the rhesus monkeys analyzed by 2TC model

Animal	Parameter	THA	Pons	CB	CAU	PUT	FC	ACC	TC	WB
Rhesus monkey 1	V _T (baseline)	31.0	35.2	23.7	26.2	26.7	25.2	28.6	25.6	23.1
	V _T (Blocking (1.5 mg/kg))	29.6	26.8	20.4	22.0	22.8	20.6	22.5	21.8	18.6
	% decrease of V _T ^a	4.5	23.9	13.9	16.0	14.6	18.3	21.3	14.8	19.5
Rhesus monkey 2	V _T (baseline)	15.7	16.9	12.8	17.0	15.8	14.3	15.5	12.3	12.6
	V _T (Blocking (4.5 mg/kg))	11.9	10.9	9.0	9.2	10.1	8.6	9.0	8.9	8.5
	% decrease of V _T ^a	24.2	35.5	29.7	45.9	36.1	39.9	41.9	27.6	32.5

^aPercent decrease of values from baseline study to blocking study. ACC, anterior cingulate cortex; CAU, caudate; CB, cerebellum; FC, frontal cortex; PUT, putamen; TC, temporal cortex; THA, thalamus; WB, whole brain.