Skip to main content

Table 2 Total distribution volume (  V T ) in brain regions of the rhesus monkeys analyzed by 2TC model

From: Synthesis and evaluation of 2-chloro N-[(S)-{(S)-1-[11 C]methylpiperidin-2-yl} (phenyl)methyl]3-trifluoromethyl-benzamide ([11 C]N-methyl-SSR504734) as a PET radioligand for glycine transporter 1

Animal Parameter THA Pons CB CAU PUT FC ACC TC WB
Rhesus monkey 1 V T (baseline) 31.0 35.2 23.7 26.2 26.7 25.2 28.6 25.6 23.1
  V T (Blocking (1.5 mg/kg)) 29.6 26.8 20.4 22.0 22.8 20.6 22.5 21.8 18.6
  % decrease of V T a 4.5 23.9 13.9 16.0 14.6 18.3 21.3 14.8 19.5
Rhesus monkey 2 V T (baseline) 15.7 16.9 12.8 17.0 15.8 14.3 15.5 12.3 12.6
  V T (Blocking (4.5 mg/kg)) 11.9 10.9 9.0 9.2 10.1 8.6 9.0 8.9 8.5
  % decrease of V T a 24.2 35.5 29.7 45.9 36.1 39.9 41.9 27.6 32.5
  1. aPercent decrease of values from baseline study to blocking study. ACC, anterior cingulate cortex; CAU, caudate; CB, cerebellum; FC, frontal cortex; PUT, putamen; TC, temporal cortex; THA, thalamus; WB, whole brain.