Skip to main content
EJNMMI Research
Figure 3 | EJNMMI Research

Figure 3

From: Synthesis and evaluation of 2-chloro N-[(S)-{(S)-1-[11 C]methylpiperidin-2-yl} (phenyl)methyl]3-trifluoromethyl-benzamide ([11 C]N-methyl-SSR504734) as a PET radioligand for glycine transporter 1

Figure 3

In vitro  postmortem autoradiography study of human brain. Autoradiogram from coronal (panels A, B, and C; 100-mm thickness) and horizontal whole-hemisphere (panels D, E, and F; 100-mm thickness) cryosections of the human brain incubated with [11 C]N-methyl-SSR504734 under baseline (panels A and D), blocked by non-radioactive N-methyl-SSR504734 (10 μM; panels B and E), and blocked by SSR504734 (10 μM; panels C and F) conditions. The quantified values of [11 C]N-methyl-SSR504734 (C) were expressed as (PSL-BG)/mm2 (panel G). TC, temporal cortex; PUT, putamen; CAU, caudate nucleus; CB, cerebellum; WM, white matter.

Back to article page