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Table 5 Results of Logan analysis using metabolite-corrected plasma input and metabolite-corrected brain data

From: [11C]phenytoin revisited: synthesis by [11C]CO carbonylation and first evaluation as a P-gp tracer in rats

 

Hippocampus

Occipital cortex

Parietal cortex

Caudate putamen

Cerebellum

Baseline (n = 5) (V T)

0.96 ± 0.09

0.91 ± 0.06

0.91 ± 0.08

0.98 ± 0.08

1.02 ± 0.08

Tariquidar

     

(n = 5) (V T)

1.43 ± 0.07

1.30 ± 0.11

1.35 ± 0.11

1.48 ± 0.12

1.48 ± 0.09

Probenecid

     

(n = 2) (V T)

0.59 ± 0.00

0.59 ± 0.00

0.57 ± 0.03

0.57 ± 0.01

0.61 ± 0.01