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Table 5 Results of Logan analysis using metabolite-corrected plasma input and metabolite-corrected brain data

From: [11C]phenytoin revisited: synthesis by [11C]CO carbonylation and first evaluation as a P-gp tracer in rats

  Hippocampus Occipital cortex Parietal cortex Caudate putamen Cerebellum
Baseline (n = 5) (V T) 0.96 ± 0.09 0.91 ± 0.06 0.91 ± 0.08 0.98 ± 0.08 1.02 ± 0.08
Tariquidar      
(n = 5) (V T) 1.43 ± 0.07 1.30 ± 0.11 1.35 ± 0.11 1.48 ± 0.12 1.48 ± 0.09
Probenecid      
(n = 2) (V T) 0.59 ± 0.00 0.59 ± 0.00 0.57 ± 0.03 0.57 ± 0.01 0.61 ± 0.01