Effects of lesion size on DSC. Box plots illustrating the effects of lesion size on DSC obtained using (local) rigid and non-rigid registration strategies. DSC values were obtained from (a) large lesions (n = 8; average: 166 ml, range: 48-749 ml) or (b) small lesions (n = 16; average: 13 ml, range: 1.1-33 ml). Reference shows the largest overlap in volume that could be achieved for VOI delineated on both scans separately. The mean is illustrated by a square, outliers by dots, and minimum and maximum values by crosses.