EJNMMI Research

Table 4 One-tissue compartment model parameters using defluorination-corrected plasma input curves

From: Decreased defluorination using the novel beta-cell imaging agent [¹⁸F]FE-DTBZ-d4 in pigs examined by PET

Parameter	Unit	Exp 1	Exp 2	Exp 3		Average	SEM
[¹⁸F]FE-DTBZ
K ₁	(cc/min)/cc	0.27	0.30	0.20		0.26	0.03
k ₂	1/min	0.08	0.07	0.04		0.064	0.01
V _T ^b	cc/cc	3.39	4.47	4.65		4.17	0.39
Chi-square fit		29.2	19.1	13.3
[¹⁸F]FE-DTBZ-d4^a
K ₁	(cc/min)/cc	0.65	1.09	1.13	0.36	0.81	0.18
k ₂	1/min	0.32	0.25	0.37	0.10	0.26	0.06
V _T ^b	cc/cc	2.05	4.39	3.06	3.64	3.69	0.49
Chi-square fit		6.8	4.0	3.7	2.7

^aResults for [¹⁸F]FE-DTBZ-d4 are compared to a reanalysis of [¹⁸F]FE-DTBZ.^bThe total distribution volume (V _T) is calculated from the rate constant ratio K ₁/k ₂. V _T is not affected by deuterization even though both K ₁ and k ₂ are increased. SEM, standard error of the mean.

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