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Table 4 One-tissue compartment model parameters using defluorination-corrected plasma input curves

From: Decreased defluorination using the novel beta-cell imaging agent [18F]FE-DTBZ-d4 in pigs examined by PET

Parameter Unit Exp 1 Exp 2 Exp 3   Average SEM
[18F]FE-DTBZ
K 1 (cc/min)/cc 0.27 0.30 0.20   0.26 0.03
k 2 1/min 0.08 0.07 0.04   0.064 0.01
V T b cc/cc 3.39 4.47 4.65   4.17 0.39
Chi-square fit   29.2 19.1 13.3    
[18F]FE-DTBZ-d4a
K 1 (cc/min)/cc 0.65 1.09 1.13 0.36 0.81 0.18
k 2 1/min 0.32 0.25 0.37 0.10 0.26 0.06
V T b cc/cc 2.05 4.39 3.06 3.64 3.69 0.49
Chi-square fit   6.8 4.0 3.7 2.7   
  1. aResults for [18F]FE-DTBZ-d4 are compared to a reanalysis of [18F]FE-DTBZ.bThe total distribution volume (V T) is calculated from the rate constant ratio K 1/k 2. V T is not affected by deuterization even though both K 1 and k 2 are increased. SEM, standard error of the mean.