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EJNMMI Research
Figure 2 | EJNMMI Research

Figure 2

From: Quantitative assessment of brown adipose tissue metabolic activity and volume using 18F-FDG PET/CT and β3-adrenergic receptor activation

Figure 2

A schematic showing the activation of a brown adipose cell. (1) Agonists (norepinephrine and CL316,243) activate the β3-AR. (2) Production of cyclic adenosine monophosphate (cAMP) and protein kinase A (PKA) triggers lipase and hydrolysis of triglycerides. (3) The UCP-1 in the mitochondria increases the breakdown of fatty acids in the cell. (4) Increased metabolic activity in the mitochondria increases glucose and 18F-FDG uptake. (5) 18F-FDG-6-phosphate uptake in the cell increases and is measured by PET. (6) Outcome of this cascade of events is the formation of heat.

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