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Table 5 Common biological processes

From: Effects of internal low-dose irradiation from 131I on gene expression in normal tissues in Balb/c mice

Tissue combination

Biological process

Kidney cortex-kidney medulla

Amiloride transport

 

Amino acid transport

 

Bone remodeling

 

Canalicular bile acid transport

 

Choline metabolism

 

Negative regulation of cell adhesion

 

Negative regulation of enzyme activity

 

Positive regulation of actin filament polymerization

 

Protection from natural killer cell mediated cytotoxicity

 

Regulation of hormone secretion

 

Transport

Kidney cortex-liver

Acetyl-CoA metabolism

 

Cytolysis

 

Response to sterol depletion

 

Retinoid metabolism

 

Steroid biosynthesis

 

Thermoregulation

Kidney cortex-lung

Cellular response to starvation

 

Cytoskeleton organization and biogenesis

 

Fatty acid oxidation

 

Patterning of blood vessels

 

Positive regulation of glucose import

 

Positive regulation of lipid metabolism

 

Protein folding

 

Regulation of transcription from RNA polymerase II promoter

Kidney cortex-spleen

Regulation of axon extension

 

Regulation of neuronal synaptic plasticity

 

Response to oxidative stress

 

Ubiquitin-dependent protein catabolism

Kidney medulla-liver

Digestion

Kidney medulla-lung

Cell migration

 

Cell-matrix adhesion

 

Cellular defense response

 

Positive regulation of angiogenesis

 

Positive regulation of neurotransmitter secretion

 

Regulation of locomotion

 

Regulation of long-term neuronal synaptic plasticity

 

Response to hypoxia

 

Synaptic vesicle transport

Kidney medulla-spleen

Cartilage condensation

 

Central nervous system development

 

Complement activation; alternative pathway

 

Neuropeptide signaling pathway

 

Positive regulation of small GTPase mediated signal transduction

 

Response to nutrient

 

S-adenosylmethionine biosynthesis

Liver-lung

Embryonic heart tube development

 

Fatty acid metabolism

 

Metabolism

Liver-spleen

Negative regulation of signal transduction

 

Regulation of cell growth

Lung-spleen

Iron ion homeostasis

 

Peptidoglycan metabolism

 

Response to biotic stimulus

Kidney cortex-kidney medulla-lung

Negative regulation of apoptosis

Kidney cortex-kidney medulla-spleen

Defense response

Kidney cortex-liver-lung

Acute-phase response

 

Complement activation

 

Lipid metabolism

Kidney cortex-lung-spleen

Response to glucose stimulus

Kidney medulla-lung-spleen

Positive regulation of non-apoptotic programmed cell death

Liver-lung-spleen

Response to heat

 

Response to unfolded protein

Kidney cortex-kidney medulla-liver-lung

Electron transport

Kidney cortex-kidney medulla-lung-spleen

Inflammatory response

 

Negative regulation of gluconeogenesis

 

Negative regulation of lipoprotein lipase activity

 

Positive regulation of fatty acid metabolism

 

Positive regulation of signal transduction

Kidney cortex-kidney medulla-liver-lung-spleen

Immune response

  1. Biological processes affected in two or more tissues independent of the absorbed dose. All processes had a p value < 0.05. Additional information is presented in Additional file 1.