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EJNMMI Research
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Table 1 Growth inhibition for tumor volume of 500 and 1,000 mm3 after treatment

From: Experimental α-particle radioimmunotherapy of breast cancer using 227Th-labeled p-benzyl-DOTA-trastuzumab

Treatment Dosage 500 mm 3 1,000 mm 3
   Days a Growth delay b Days Growth delay
NaCl   15 ± 7 0 ± 10 25 ± 7 0 ± 11
Trastuzumab (pooled) 20 - 250 μg 15 ± 7 0 ± 11 23 ± 8 -2 ± 12
227Th-rituximab 400 and 600 kBq/kg 15 ± 8 -3 ± 11 27 ± 10 2 ± 11
227Th-trastuzumab 200 kBq/kg 22 ± 8 7 ± 11 32 ± 8 7 ± 12
227Th-trastuzumab 400 kBq/kg 38 ± 8 23 ± 10 70 ± 10 45 ± 12
227Th-trastuzumab 600 kBq/kg 60 ± 7 45 ± 7 90 ± 10 65 ± 7
  1. aThe number of days to reach the chosen tumor volume. bGrowth delay = days (treatment) - days (NaCl).
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