Treatment
|
Dosage
|
500 mm
3
|
1,000 mm
3
|
---|
| |
Days
a
|
Growth delay
b
|
Days
|
Growth delay
|
NaCl
| |
15 ± 7
|
0 ± 10
|
25 ± 7
|
0 ± 11
|
Trastuzumab (pooled)
|
20 - 250 μg
|
15 ± 7
|
0 ± 11
|
23 ± 8
|
-2 ± 12
|
227Th-rituximab
|
400 and 600 kBq/kg
|
15 ± 8
|
-3 ± 11
|
27 ± 10
|
2 ± 11
|
227Th-trastuzumab
|
200 kBq/kg
|
22 ± 8
|
7 ± 11
|
32 ± 8
|
7 ± 12
|
227Th-trastuzumab
|
400 kBq/kg
|
38 ± 8
|
23 ± 10
|
70 ± 10
|
45 ± 12
|
227Th-trastuzumab
|
600 kBq/kg
|
60 ± 7
|
45 ± 7
|
90 ± 10
|
65 ± 7
|
-
aThe number of days to reach the chosen tumor volume. bGrowth delay = days (treatment) - days (NaCl).