Biodistribution of 227
Th-conjugates and 223
Ra in mice with SKBR-3 xenografts. Biodistribution profile of 227Th-trastuzumab (a) and daughter nuclide 223 Ra (c) after administration of 227Th-trastuzumab, and biodistribution of 227Th-rituximab (b) and daughter nuclide 223 Ra (d) after administration 227Th-rituximab, in mice bearing SKBR-3 xenografts. The measured 227Th activities were normalized to an injection of 400 kBq/kg bodyweight. Values are mean ± SD. N = 6 for each time point except at day 3, where N = 5.