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Table 1 Percentage of the parent compound (11C-dLop) in plasma

From: P-glycoprotein at the blood-brain barrier: kinetic modeling of 11C-desmethylloperamide in mice using a 18F-FDG μPET scan to determine the input function

Mouse strain and pretreatment % 11 C-desmethylloperamide in plasma
  1 min p.i. 10 min p.i. 30 min p.i.
WT, saline 95 ± 1 72 ± 5 53 ± 3
WT, 50 mg cyclosporine/kg 95 ± 1 54 ± 5 23 ± 9
KO 98 ± 1 51 ± 1 34 ± 9
  1. Percentage of the parent compound (11C-dLop) in plasma at 1, 10, and 30 min p.i. in different mouse strains and after different pretreatments. Results are expressed as percent of total radioactivity ± standard deviation. WT, wild-type mice; KO, knock-out mice.