P-glycoprotein at the blood-brain barrier: kinetic modeling of 11C-desmethylloperamide in mice using a 18F-FDG μPET scan to determine the input function

EJNMMI Research

Table 1 Percentage of the parent compound (¹¹C-dLop) in plasma

Mouse strain and pretreatment	% ¹¹ C-desmethylloperamide in plasma
	1 min p.i.	10 min p.i.	30 min p.i.
WT, saline	95 ± 1	72 ± 5	53 ± 3
WT, 50 mg cyclosporine/kg	95 ± 1	54 ± 5	23 ± 9
KO	98 ± 1	51 ± 1	34 ± 9

Percentage of the parent compound (¹¹C-dLop) in plasma at 1, 10, and 30 min p.i. in different mouse strains and after different pretreatments. Results are expressed as percent of total radioactivity ± standard deviation. WT, wild-type mice; KO, knock-out mice.