Predictive value of 99mTc-MAA-based dosimetry in personalized 90Y-SIRT planning for liver malignancies

Riveira-Martin, Mercedes; Akhavanallaf, Azadeh; Mansouri, Zahra; Bianchetto Wolf, Nicola; Salimi, Yazdan; Ricoeur, Alexis; Mainta, Ismini; Garibotto, Valentina; López Medina, Antonio; Zaidi, Habib

doi:10.1186/s13550-023-01011-3

EJNMMI Research

Table 2 Absorbed dose distribution parameters (MAD, D50, D70, D95 (Gy/GBq) and V120, V205, V20, V50, V90 (%)) compared between simulation (^99mTc-MAA) and therapy (⁹⁰Y) for all cases in TL, NTLt and NTLw

From: Predictive value of ^99mTc-MAA-based dosimetry in personalized ⁹⁰Y-SIRT planning for liver malignancies

Segment	Metric	^99mTc-MAA	⁹⁰Y	Wilcoxon p-value	Pearson's r correlation	Relative difference (%) mean [range]^a
TL	MAD (Gy/GBq)	85.36 ± 79.97	67.55 ± 55.34	0.11	0.95 (P < .001)	25.64 [− 47.32–170.38]
	D50 (Gy/GBq)	71.57 ± 64.25	62.82 ± 54.53	0.52	0.95 (P < .001)	14.06 [− 63.17–203.4]
	D70 (Gy/GBq)	53.88 ± 58.27	49.8 ± 44.75	0.66	0.95 (P < .001)	1.53 [− 78.95–110.75]
	D95 (Gy/GBq)	27.46 ± 43.14	29.85 ± 28.44	0.01*	0.89 (P < .001)	− 26.44 [− 89.72–112.56]
	V120 (%)	25.41 ± 21.73	21.24 ± 20.29	0.15	0.89 (P < .001)	–
	V205 (%)	13.86 ± 17.21	8.87 ± 15.06	< 0.001*	0.81 (P < .001)	–
NTLt	MAD (Gy/GBq)	32.57 ± 20.37	32.28 ± 16.92	0.67	0.97 (P < .001)	− 2.36 [− 59.57–60.26]
	D50 (Gy/GBq)	22.67 ± 18.42	26.68 ± 16.22	0.01*	0.93 (P < .001)	− 20.38 [− 92.5–134.02]
	D70 (Gy/GBq)	13.5 ± 12.53	18.98 ± 12.43	< 0.001*	0.88 (P < .001)	− 34.26 [− 96.11–170.74]
	D95 (Gy/GBq)	4.04 ± 4.57	9.67 ± 6.85	< 0.001*	0.79 (P < .001)	− 62.13 [− 97.29–31.55]
	V20 (%)	32.8 ± 20.68	39.81 ± 21.88	< 0.001*	0.96 (P < .001)	− 18.71 [− 66.70–15.50]
	V50 (%)	21.71 ± 15.38	24.83 ± 16.61	0.04*	0.92 (P < .001)	− 9.41 [− 85.24–103.02]
	V90 (%)	12.38 ± 9.59	11.97 ± 8.37	0.96	0.88 (P < .001)	36.40 [− 93.10–1857.72]
NTLw	MAD (Gy/GBq)	18.67 ± 8.37	20.58 ± 7.46	0.10	0.95 (P < .001)	− 11.48 [− 60.30–17.82]
	D50 (Gy/GBq)	8.24 ± 7.05	13.83 ± 7.43	< 0.001*	0.84 (P < .001)	− 46.00 [− 92.31–53.27]
	D70 (Gy/GBq)	3.20 ± 4.20	7.98 ± 4.99	< 0.001*	0.82 (P < .001)	− 65.44 [− 95.21–5.99]
	D95 (Gy/GBq)	0.88 ± 1.72	3.1 ± 2.53	< 0.001*	0.82 (P < .001)	− 73.2 [− 96.66–35.30]
	V20 (%)	18.5 ± 8.06	24.86 ± 8.88	< 0.001*	0.88 (P < .001)	− 26.54 [− 73.53–17.12]
	V50 (%)	11.71 ± 6.15	13.78 ± 6.85	0.03*	0.84 (P < .001)	− 9.07 [− 85.78–345.82]
	V90 (%)	6.58 ± 3.87	6.78 ± 4.34	0.92	0.86 (P < .001)	115.36 [− 91.64–8574.56]

^*Wilcoxon's p-value P < 0.05
^aIn cases where there was a null value in the quotient, the result is not shown (–)

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