EJNMMI Research

Table 6 Histological evaluation of renal radiation injury in mice injected with ¹⁶¹Tb-folate or ¹⁷⁷Lu-folate, indicated with partial scores for glomeruli, tubules, and interstitium

From: Contribution of Auger/conversion electrons to renal side effects after radionuclide therapy: preclinical comparison of ¹⁶¹Tb-folate and ¹⁷⁷Lu-folate

	Control	¹⁶¹Tb-folate			¹⁷⁷Lu-folate
	Group A^a(n = 9)	Group B: 10 MBq	Group C: 20 MBq	Group D: 30 MBq	Group E: 10 MBq	Group F: 20 MBq	Group G:30 MBq
	Group A^a(n = 9)	(n = 5)^a	(n = 5)^a	(n = 2)^b	(n = 5)^a	(n = 4)^a	(n = 5)^b
Glomeruli	0	1.1	3.4	5.0	2.0	3.8	5.0
Tubules	0	0.9	2.4	4.5	1.5	3.3	4.2
Interstitium	0	0.4	1.8	4.0	0.4	3.3	4.6
Cumulative score	0	2.4	7.6	13.5	3.9	10.4	13.8
Final score	0	1	3	4	2	3	4

The sum of the partial scores determined the cumulative scores, which were then converted to the final score as a measure for the different degrees of renal injury
^aMice euthanized in Week 34
^bMice euthanized between Weeks 15 and 26

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