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EJNMMI Research
Fig. 5 | EJNMMI Research

Fig. 5

From: In-vivo inhibition of neutral endopeptidase 1 results in higher absorbed tumor doses of [177Lu]Lu-PP-F11N in humans: the lumed phase 0b study

Fig. 5

Detection of a lymph node metastasis by [177Lu]Lu-PP-F11N SPECT/CT in patient 8. Corresponding axial CT (A), [177Lu]Lu-PP-F11N SPECT/CT (B) and MIP (C) of patient 8, showing focal tracer uptake in a left cervical lymph node (arrows) only after Entresto® pretreatment (see Fig. 2). Corresponding images (E–G) of the 68Ga-DOTATOC PET/CT without visible tracer uptake (arrowheads). The corresponding lymph node is visible in the contrast medium enhanced CT (E, 6 mm). Hematoxylin and Eosin (D) and SSTR2 (H) staining of the lymph node after resection, showing metastasis of MTC, negative for SSTR2

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