Biodistribution and dosimetry of 177Lu-DOTA-IBA for therapy of bone metastases

EJNMMI Research

Table 2 The normalized ADs for the target organs (mGy/MBq)

Organ	Patient no					Mean (n = 5)	SD
Organ	1	2	3	4	5	Mean (n = 5)	SD
Liver	0.169	0.091	0.132	0.045	0.036	0.095	0.051
Kidneys	0.145	0.112	0.078	0.110	0.127	0.114	0.022
Spleen	0.131	0.168	0.127	0.119	0.061	0.121	0.035
Red marrow	0.121	0.080	0.069	0.084	0.120	0.095	0.022
Bladder	0.317	0.298	0.318	0.302	0.431	0.333	0.050
Osteogenic cells	0.826	0.570	0.487	0.621	0.779	0.657	0.127
Effective dose	0.068	0.050	0.050	0.046	0.061	0.055	0.008
Maximum tolerated injected activity (GBq)	16.5	25.2	28.9	23.8	16.7	22.2	4.9