Fig. 1

(A) Cohort-1 study. Coronal ¹⁸F-FDG-PET images from the same patient imaged 7 days apart with SUVmax values indicated. (B) Cohort-2 study. Sagittal ¹⁸F-FDG-PET images of a 90-year old female with bone-dominant MBC. Left: Pre-therapy baseline scan showing the SULpeak of the index lesion. Right: Post therapy 4mo scan, that shows a decrease of 25%, which met our LRC threshold of -18%, but not the PERCIST threshold of -30%. The SUVmax of the index lesion decreased by 22%. The response was considered stable disease by the criteria developed in this report