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EJNMMI Research
Fig. 1 | EJNMMI Research

Fig. 1

From: Non-specific irreversible 89Zr-mAb uptake in tumours: evidence from biopsy-proven target-negative tumours using 89Zr-immuno-PET

Fig. 1

Distribution of 89Zr-mAbs in healthy tissue: A convection of mAbs across the vascular endothelium into the interstitial space and return to circulation via lymphatic system; B mAb uptake into endothelial cells via pinocytosis and FcRn-mediated return to vascular or interstitial space; C catabolism of FcRn-unbound mAbs; D binding to target receptors. Based on Lobo et al. [4]

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