Fig. 5

Schematic diagram of the systemic metabolism network constructed via total-body SUV images and partial Pearson correlation coefficients. a 18 ROIs including 11 organs and 7 brain regions, according to Sun et al. [63]. b Illustration of group-level network analysis. c Illustration of individual-level network analysis. Based on the total-body uptake measures (i.e., SUV) images from multi-parameter information obtained by the uEXPLORER, systemic metabolic network can be constructed by calculating the partial Pearson partial correlation coefficient of the uptake measures between the two regions. The group-level differential network is calculated as the difference between the group-level networks of control and patient groups. In terms of individual-level differential network, a reference network of the control group is obtained, then a patient is added to the control group to form a new group, and a network of disturbance connections called the perturbation network is constructed using the same steps. The difference between the perturbation network and the reference network is labeled as the individual-level differential network to describe the deviated metabolic connectivity from the reference network. Abbreviations: RefNET, reference network; ConNET, control group network; PaNET, patient group network; PtbNET, perturbed network