Fig. 6
From: Characterization of a novel model for atherosclerosis imaging: the apolipoprotein E-deficient rat
Representative images of ORO-stained aortic arches from an Ctrl rat (a) and an apoE−/− rat (b), respectively, after treatment of 51 ± 1 weeks with a Western diet. The arch of the apoE−/− rat is less uniform with more intense red areas (indicated by the white arrows). 1, Ascending aorta 2, Brachiocephalic artery, 3, Left common carotid artery, 4, Left subclavian artery, 5, Descending aorta, 6, Aortic arch. (c) Lipid-loaden atherosclerotic plaques presented as ORO positive area/total arch area. Representative images of ED1 staining (red) in the abdominal aorta from an Ctrl rat (d) and an apoE−/− rat (e). Inserts represent a magnification (×20) of highlighted sections. (f) Quantification of the ED1 positive signal in the aortic intima presented as number of strong positive pixels/total surface (Nsp/Atot). Data are presented as mean ± SEM. * is considered significantly different with a p-value < 0.05