Fig. 2

Comparing IDIF sites for brain PET. Comparison of three IDIF extraction sites (common carotid artery (CCA); internal carotid artery (ICA); superior sagittal sinus (SSS)) in 38 patients with glioma (brain PET acquisitions performed on a Biograph mMR scanner). IDIF curves (after the peak, fitted with a three-exponential decay model, and normalized by their maximum) shown at the individual (colored) and population mean (black) level for each extraction site (panel A: CCA, panel B: ICA, panel C: SSS). SSS had the highest between-subject variability, and CCA had the lowest. Panel D shows the mean fitted IDIFs (full-time course on the left, 20–50-min portion on the right). The curves are almost parallel, with CCA as the lowest and SSS the highest, thus suffering from highest spillover. As a note, the diameters of the three vessels are: CCA ~ 6 to 7 mm, ICA ~ 4 to 5 mm, SSS ~ 3 to 4 mm