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EJNMMI Research
Fig. 4 | EJNMMI Research

Fig. 4

From: Development of [89Zr]Zr-hCD103.Fab01A and [68Ga]Ga-hCD103.Fab01A for PET imaging to noninvasively assess cancer reactive T cell infiltration: Fab-based CD103 immunoPET

Fig. 4

In vivo [89Zr]Zr-hCD103.Fab01A and [68Ga]Ga-hCD103.Fab01A microPET imaging A Representative coronal and sagittal [68Ga]Ga-hCD103.Fab01A PET scans, 3 h post-tracer injection in CHO.CD103 (top panel) and CHO.K1 xenograft mice (bottom panel). Xenograft area marked with asterix. In vivo [68Ga]Ga-hCD103.Fab01A xenograft-to-blood ratio, 3 h post-tracer injection, are expressed as SUVmean. B Ex vivo xenograft uptake (%ID/g) and xenograft-to-blood ratio of 6[68Ga]Ga-hCD103.Fab01A, 3 h post-tracer injection. C Representative coronal [89Zr]Zr-hCD103.Fab01A PET scans, 3, 6 and 24 h post-tracer injection in CHO.CD103 (top panel) and CHO.K1 xenograft mice (bottom panel). Xenograft area marked with asterix. In vivo [89Zr]Zr-hCD103.Fab01A xenograft-to-blood ratio, 24 h post-tracer injection, are expressed as SUVmean. D Ex vivo xenograft uptake (%ID/g) and xenograft-to-blood ratio of [89Zr]Zr-hCD103.Fab01A, 24 h post-tracer injection. *, p < 0.05. E–F Ex vivo tissue uptake (%ID/g) of [68Ga]Ga-hCD103.Fab01A (E) and [89Zr]Zr-hCD103.Fab01A (F) in CHO.CD103 and CHO.K1 xenograft bearing mice

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