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EJNMMI Research

Table 2 Differences in MTV between EARL2 versus EARL1 using multiple segmentation methods

From: Quantitative and clinical implications of the EARL2 versus EARL1 [18F]FDG PET-CT performance standards in head and neck squamous cell carcinoma

Segmentation method for MTV

Median MTV EARL1 (cm3)

Median MTV EARL2 (cm3)

Median difference* (cm3)

Median difference* (%)

p value

Adaptive threshold

9.4 (4.8–18)

9.7 (5.0–17)

− 0.2 (− 0.6 to 0.1)

− 2.4 (− 5.7 to 0.7)

0.003

SUV2.5

14.5 (5.4–25)

14.7 (6.1–25)

0.1 (− 0.1 to 0.4)

1.6 (− 0.3 to 6.1)

0.024

SUV3.5

9.2 (3.4–18)

9.6 (3.6–18)

0.4 (0.3–0.6)

4.7 (1.7–14)

 < 0.001

SUV4.5

6.0 (2.1–13)

6.8 (2.5–14)

0.7 (0.4–0.9)

11.3 (5.2–25)

 < 0.001

SUR2.5

5.4 (2.6–15)

5.8 (2.4–14)

0.1 (− 0.4 to 0.2)

0.7 (− 2.8 to 11)

0.712

SUR3.5

3.4 (1.3–9.6)

3.7 (1.7–9.5)

0.2 (0.0–0.4)

9.2 (1.1–21)

0.001

SUR4.5

2.4 (0.6–6.6)

2.7 (0.9–7.2)

0.3 (0.2–0.6)

15 (8.1–43)

 < 0.001

MAX40%

7.0 (3.3–12)

6.7 (2.9–10)

− 0.4 (− 0.9 to − 0.1)

− 7.5 (− 17 to − 2)

 < 0.001

MAX50%

4.3 (2.0–7.6)

4.0 (1.8–7.6)

− 0.1 (− 0.4 to 0.2)

− 4.1 (− 20.1 to 2.5)

0.250

  1. Absolute and relative differences between EARL1 and EARL2 are calculated in reference to EARL1
  2. *Median based on the differences of paired data. Values in parentheses represent the interquartile range
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