[18F]FDG PET-MR characterization of aortitis in the IL1rn−/− mouse model of giant-cell arteritis

Deshayes, Samuel; Baugé, Caroline; Dupont, Pierre-Antoine; Simard, Christophe; Rida, Hanan; de Boysson, Hubert; Manrique, Alain; Aouba, Achille

doi:10.1186/s13550-023-01039-5

EJNMMI Research

Table 1 Results of histological stainings of mice aorta

From: [¹⁸F]FDG PET-MR characterization of aortitis in the IL1rn^−/− mouse model of giant-cell arteritis

	IL1rn^−/− (n = 15)	Wild-type (n = 15)	p Value
Thoracic aorta
CD4	5.16 ± 1.95	6.85 ± 1.69	0.38
CD8	6.08 ± 1.47	13.07 ± 6.09	0.63
CD11c	13.31 ± 2.64	9.29 ± 1.79	0.19
CD20	11.83 ± 3.33	9.53 ± 3.42	0.33
CD31	519.51 ± 18.52 (n = 14)	525.31 ± 21.68	0.92
CD68	10.83 ± 3.10	9.47 ± 1.96	0.97
CD163	10.43 ± 1.56	7.83 ± 2.27	0.07
Interferon-γ	100.71 ± 19.31	71.10 ± 14.40 (n = 14)	0.21
Interleukin-1α	39.82 ± 9.48	54.11 ± 15.81	0.57
Interleukin-1β	38.51 ± 9.96	41.22 ± 14.34	0.35
Interleukin-6	25.54 ± 10.00	21.45 ± 7.01 (n = 14)	0.95
Interleukin-17A	361.53 ± 24.98	347.04 ± 20.85	0.75
Haematoxylin–eosin-saffron stain^a	8348.63 ± 295.7	8507.03 ± 274.2	0.55
Abdominal aorta
CD4	1.50 ± 0.45 (n = 14)	3.96 ± 1.11	0.11
CD8	4.38 ± 1.50	2.69 ± 0.41	1
CD11c	13.19 ± 3.68	8.95 ± 2.18 (n = 14)	0.36
CD20	31.15 ± 10.14	16.61 ± 7.22 (n = 14)	0.41
CD31	597.56 ± 21.93 (n = 14)	584.45 ± 13.80	0.92
CD68	8.02 ± 2.01	9.83 ± 1.97	0.52
CD163	3.93 ± 1.32	4.41 ± 0.79	0.13
Interferon-γ	74.27 ± 11.69	55.84 ± 12.23	0.17
Interleukin-1α	48.53 ± 6.12	31.34 ± 6.22	0.056
Interleukin-1β	46.26 ± 16.52	11.88 ± 2.28	0.021
Interleukin-6	26.45 ± 5.17	13.44 ± 2.85	0.019
Interleukin-17A	363.19 ± 26.73	340.98 ± 12.67	0.88
Haematoxylin–eosin-saffron stain^a	7964.49 ± 141.6	8175.01 ± 169.6	0.57
Whole aorta
CD4	3.33 ± 0.95	5.32 ± 1.02	0.18
CD8	4.96 ± 0.92	10.31 ± 5.01	0.81
CD11c	12.51 ± 2.08	9.75 ± 1.68	0.42
CD20	19.05 ± 4.45	12.58 ± 4.52	0.17
CD31	537.08 ± 17.27	550.10 ± 17.74	0.39
CD68	10.08 ± 2.11	10.05 ± 1.70	0.66
CD163	7.65 ± 1.01	5.89 ± 1.08	0.14
Interferon-γ	85.39 ± 10.91	59.43 ± 8.99	0.098
Interleukin-1α	42.64 ± 8.05	51.19 ± 12.95	0.94
Interleukin-1β	31.19 ± 5.88	33.01 ± 11.75	0.31
Interleukin-6	25.36 ± 5.40	17.10 ± 4.16	0.25
Interleukin-17A	360.30 ± 21.28	345.98 ± 15.16	0.54
Haematoxylin–eosin-saffron stain^a	8127.59 ± 161.7	8202.92 ± 185.1	0.54

Unless indicated, values are displayed as the mean number of positive cells per thousand (± SEM). Significant values (i.e. p value < 0.05) are displayed in bold
^aExpressed as the mean number of cells per mm² (± SEM)

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