Table 1 Formular of radiomics signature score (rad-score)

 + 0.056623*firstorder_Minimum_CT

 + 0.153041*firstorder_RootMeanSquared_CT

 − 0.119239*firstorder_TotalEnergy_CT

 − 0.004347*GLCM_ClusterShade_CT

 − 0.219531*GLCM_DifferenceVariance_CT

 + 0.194025*GLCM_Imc1_CT

 + 0.124174*GLCM_Imc2_CT

 + 0.085175*GLDM_DependenceEntropy_CT

 + 0.189177*GLDM_DependenceVariance_CT

 + 0.055343*GLDM_SmallDependenceLowGrayLevelEmphasis_CT

 − 0.021720*GLRLM_LongRunLowGrayLevelEmphasis_CT

 + 0.020565*GLRLM_ShortRunLowGrayLevelEmphasis_CT

 + 0.127269*GLSZM_SizeZoneNonUniformity_CT

 − 0.015686*GLSZM_SmallAreaEmphasis_CT

 + 0.157129*GLSZM_ZonePercentage_CT

 + 0.062160*NGTDM_Strength_CT

 + 0.013747*SHAPE_Elongation_CT

 − 0.310642*firstorder_10Percentile_PET

 − 0.195190*firstorder_Energy_PET

 + 0.839216*firstorder_RootMeanSquared_PET

 + 0.098178*firstorder_Skewness_PET

 + 0.021632*firstorder_TotalEnergy_PET

 − 0.282702*firstorder_Variance_PET

 + 0.095305*GLDM_DependenceNonUniformityNormalized_PET

 − 0.057897*GLDM_DependenceVariance_PET

 − 0.009464*GLDM_GrayLevelNonUniformity_PET