Assessment of resting myocardial blood flow in regions of known transmural scar to confirm accuracy and precision of 3D cardiac positron emission tomography

EJNMMI Research

Table 5 Literature review of resting MBF in transmural infarct

Author	Radiotracer or method	Mean rMBF in transmural scar (mL/min/g)	Upper limit of rMBF in scar (mL/min/g)	Number of subjects or segments	Method	Camera type	Year of publication
Rivas [3]	Microspheres	Infarcted layers with rMBF ranging 0.00–0.35	0.35	11 Dogs	Direct	NA	1976
Savage [4]	Microspheres	Infarcted layers with rMBF ranging 0.06–0.25	0.25	11 Pigs	Direct	NA	1981
de Silva [5]^§	[O-15]H₂O	0.28 ± 0.07	0.35	12 Patients	ROI	2D PET	1992
Czernin [6]	N-13	0.32 ± 0.12	0.44	13 Patients	Segmental	2D PET	1993
Bol [7]	microspheres, N-13 and [O-15]H₂O	0.26–0.35	0.35	6 Dogs	Direct and ROI	2D PET	1993
Gewirtz [8]	N-13	0.27 ± 0.17	0.44	22 Infarcted zones	Segmental	2D PET	1994
Sun [9]	N-13	0.28 ± 0.09	0.37	16 Patients	ROI	2D PET	1996
Beanlands^* [10]	N-13	0.30 ± 0.06	0.36	8 Patients	ROI	2D PET	1997
Iida [11]	Microspheres, [O-15]H₂O	0.19 ± 0.14	0.33	12 Dogs	Direct, ROI	2D PET	2000
Zhang [12]	N-13	0.32 ± 0.09	0.41	36 Regions	Segmental	2D PET	2013
Wang [2]	N-13	0.27 ± 0.06	0.33	115 Segments (~ 8 patients)	Segmental	3D PET	2020
Stewart [1]	Rb-82	0.32 ± 0.07	0.39	16 Patients	ROI	2D PET	2022
Bober	Rb-82	0.27 ± 0.05	0.33	20 Patients–60 scans	ROI	3D PET	2023

*Two data points excluded due to residual viability
^§Reported resting myocardial blood flow in perfusable tissue values were converted to resting myocardial blood flow per mass in total tissue by multiplying the perfusable tissue index (PTI) to the reported values in the conclusions. This allows for direct comparison between [O-15]-H20 and ¹³N and ⁸²Rb [35]