Threshold for defining PSMA-positivity prior to 177Lu-PSMA therapy: a comparison of [68Ga]Ga-PSMA-11 and [18F]F-DCFPyL in metastatic prostate cancer

EJNMMI Research

Table 2 Tumour-to-background ratios including contrast-to-noise ratios from OSEM-PET

Lesion no.	SUV_maxT/SUV_meanL		SUV_meanT/SUV_meanL		SUV_maxT/SUV_meanM		SUV_meanT/SUV_meanM		CNR
	⁶⁸Ga	¹⁸F	⁶⁸Ga	¹⁸F	⁶⁸Ga	¹⁸F	⁶⁸Ga	¹⁸F	⁶⁸Ga	¹⁸F
1	0.79	0.64	0.65	0.42	2.49	2.21	2.04	1.48	7.37	6.61
2	1.06	1.00	0.59	0.55	3.34	3.49	1.84	1.91	7.22	6.68
3	2.32	1.56	1.35	0.98	11.94	11.23	6.94	7.10	16.18	11.29
4	1.75	1.41	1.02	0.90	9.02	7.13	5.27	4.55	21.18	27.85
5	0.92	0.77	0.53	0.52	4.73	3.89	2.74	2.61	12.05	21.11
6	8.76	8.50	4.79	4.39	30.39	26.70	16.61	13.80	24.22	28.96
7	8.70	9.91	5.64	6.23	30.17	31.12	19.55	19.57	49.29	80.03
8	5.35	6.63	3.43	4.03	18.57	20.83	11.89	12.67	29.40	51.24
9	2.68	2.66	1.61	1.71	9.28	8.36	5.58	5.38	13.02	20.83
10	2.03	3.68	1.24	2.31	7.04	11.56	4.31	7.26	9.74	28.69
11	5.40	5.29	3.06	3.23	18.72	16.60	10.61	10.15	22.94	42.64
12	1.71	2.40	1.05	1.45	5.94	7.55	3.64	4.56	8.00	17.41
13	4.10	3.74	2.63	2.52	11.38	15.93	7.31	10.76	14.21	24.49
14	1.58	0.81	0.40	0.49	5.30	4.44	1.34	2.71	3.92	11.11
15	4.15	1.74	2.31	1.04	18.00	9.98	10.04	5.94	32.86	27.54
16	1.90	2.54	1.19	1.49	5.41	10.23	3.38	5.99	9.33	33.40
17	0.63	0.73	0.36	0.43	2.63	3.12	1.49	1.83	5.00	22.00
18	0.27	0.44	0.15	0.25	1.13	1.86	0.63	1.07	2.63	14.13
19	0.54	0.57	0.38	0.33	2.25	2.44	1.57	1.42	1.75	7.40
20	0.71	0.76	0.42	0.43	2.96	3.23	1.75	1.86	2.23	11.40
21	0.76	0.72	0.42	0.39	3.15	3.07	1.74	1.67	4.03	5.52
22	1.31	1.24	0.79	0.75	5.24	5.87	3.16	3.55	11.74	27.73
23	0.66	0.40	0.39	0.22	2.65	1.88	1.56	1.05	6.24	3.33
24	1.80	0.94	0.91	0.50	6.77	1.92	3.43	1.02	21.42	23.67

SUV standardised uptake values corrected for body weight, OSEM ordered subset expectation maximisation, PET positron emission tomography, SUVmaxT/SUVmeanL Ratio of the maximum SUV in the tumour lesion to the mean SUV in the liver, SUVmeanT/SUVmeanL Ratio of the mean SUV in the tumour lesion to the mean SUV in the liver, SUVmaxT/SUVmeanM Ratio of the maximum SUV in the tumour lesion to the mean SUV in the mediastinum, SUVmeanT/SUVmeanM Ratio of the mean SUV in the tumour lesion to the mean SUV in the mediastinum, CNR contrast-to-noise ratio, ⁶⁸Ga [⁶⁸Ga]Ga-PSMA-11, ¹⁸F [¹⁸F]F-DCFPyL