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EJNMMI Research
Fig. 3 | EJNMMI Research

Fig. 3

From: Threshold for defining PSMA-positivity prior to 177Lu-PSMA therapy: a comparison of [68Ga]Ga-PSMA-11 and [18F]F-DCFPyL in metastatic prostate cancer

Fig. 3

Boxplots of contrast-to-noise ratios in (A) OSEM and (B) HD/UHD reconstructed [68Ga]Ga-PSMA-11-PET and [18F]F-DCFPyL-PET. Boxplots depict minimum, first quartile, median, third quartile and maximum as well as outliers (circles, stars, number equals lesion ID). In general, these boxplots show that contrast-to-noise ratios were higher on PET using [18F]F-DCFPyL than on imaging with [68Ga]Ga-PSMA-11. Median contrast-to-noise ratios were 21.6 (3.3–80.0) in [18F]F-DCFPyL PET vs. 10.7 (1.8–49.3) in [68Ga]Ga-PSMA-11 PET using OSEM and 35.1 (3.3–151.5) in [18F]F-DCFPyL PET vs. 24.3 (3.1–111.2) in [68Ga]Ga-PSMA-11 PET using HD/UHD reconstruction methods. Wilcoxon test showed a highly significant difference regarding contrast-to-noise ratios in [68Ga]Ga-PSMA-11 PET and [18F]F-DCFPyL PET for both OSEM (p < 0.001) and HD/UHD (p < 0.001) reconstructed PET images. CNR contrast-to-noise ratio, 68Ga [68Ga]Ga-PSMA-11, 18F [18F]F-DCFPyL, OSEM ordered subset expectation maximisation, HD high definition, UHD ultra-high definition, PET positron emission tomography

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