Fig. 1
PET imaging of noradrenaline transporter densities in DSP-4 treated rats. Top Left: Time-activity curves of hippocampus of rats treated with 0 (open circle), 5 (triangle) and 50 mg/kg (closed circle) DSP-4. Data are average of four, five and six animals, respectively. Top Right: Binding potential in the hippocampus of rats treated with 0, 5 and 50 mg/kg DSP-4. Dunnett’s multiple comparison test showed significant differences between 0 and 50 (****: p < 0.0001) and 0 and 5 mg/kg DSP-4 (***: p < 0.001). Bottom: Averaged parametric images of rats treated with 0 (n = 4, left), 5 (n = 5, middle) and 50 mg/kg (n = 6, right) DSP-4. The coronal images in the hippocampus level were displayed with color scale units in non-displaceable binding potential (BPND) overlayed on template MR images