Dispersion-corrected extracorporeal arterial input functions in PET studies of mice: a comparison to intracorporeal microprobe measurements

EJNMMI Research

Table 4 Kinetic parameters of the modelling study

Model	Parameter	Simulated value	Fitted value using \(AI{F}_{DG}\)	Fitted value using \(AI{F}_{SG}\)	\({\chi }_{DG}^{2}\)	\({\chi }_{SG}^{2}\)
1TC-sim1	\({v}_{B}\)	0.050	0.057 ± 0.014	0.056 ± 0.023	0.899 ± 1.341	0.800 ± 1.302
	\({K}_{1}\)(min⁻¹)	0.200	0.179 ± 0.025	0.177 ± 0.025
	\({k}_{2}\)(min⁻¹)	0.100	0.093 ± 0.010	0.093 ± 0.009
	\({V}_{T}\)	2.000	1.932 ± 0.179	1.910 ± 0.184
1TC-sim2	\({v}_{B}\)	0.050	0.050 ± 0.028	0.0517 ± 0.024	0.062 ± 0.092	0.029 ± 0.025
	\({K}_{1}\)(min⁻¹)	0.200	0.182 ± 0.020	0.185 ± 0.018
	\({k}_{2}\)(min⁻¹)	0.020	0.018 ± 0.002	0.019 ± 0.002
	\({V}_{T}\)	10.00	10.135 ± 1.296	9.994 ± 1.136
2TC-sim1	\({v}_{B}\)	0.050	0.052 ± 0.006	0.045 ± 0.019	0.211 ± 0.304	0.093 ± 0.163
	\({K}_{1}\)(min⁻¹)	0.270	0.258 ± 0.047	0.253 ± 0.040
	\({k}_{2}\)(min⁻¹)	0.570	0.600 ± 0.055	0.591 ± 0.045
	\({k}_{3}\)(min⁻¹)	0.080	0.084 ± 0.012	0.083 ± 0.045
	\({k}_{4}\)(min⁻¹)	0.018	0.016 ± 0.003	0.017 ± 0.002
	\({K}_{i}\)(min⁻¹)	0.033	0.031 ± 0.002	0.031 ± 0.003
2TC-sim2	\({v}_{B}\)	0.050	0.039 ± 0.007	0.038 ± 0.016	0.014 ± 0.0169	0.023 ± 0.026
	\({K}_{1}\)(min⁻¹)	0.140	0.136 ± 0.026	0.136 ± 0.024
	\({k}_{2}\)(min⁻¹)	0.190	0.217 ± 0.039	0.221 ± 0.042
	\({k}_{3}\)(min⁻¹)	0.070	0.078 ± 0.039	0.077 ± 0.042
	\({k}_{4}\)(min⁻¹)	0.005	0.004 ± 0.002	0.004 ± 0.002
	\({K}_{i}\)(min⁻¹)	0.038	0.036 ± 0.003	0.035 ± 0.003

Simulated and modelled parameters along with goodness-of-fits \({\chi }^{2}\) for the investigated compartment models using \(AI{F}_{DG}\) and \(AI{F}_{SG}\), presented as mean ± SD