Fig. 1
From: Fc-engineered monoclonal antibodies to reduce off-target liver uptake
Liver accumulation of a bacterial anti-beta galactosidase IgG is reduced by the LALAPG triple mutation. A Maximal Intensity Projection (MIP) PET images of mice subcutaneously xenografted with myoblasts (left flank) at 48, 72 and 96 h after the injection of 89Zr-radioimmunolabeled 13R4a with LALAPG Fc or with WT Fc (n = 2 mice per group). The low and high values correspond to 1 and 5% IA/cm3 respectively and are indicated by a low and high line on the scale. B Quantitative PET analysis (PET based) of antibody accumulation in liver at different times post-injection (48 h, 72 h and 96 h) expressed in %IA/cm3