Impact of brain segmentation methods on regional metabolism quantification in 18F-FDG PET/MR analysis

EJNMMI Research

Table 2 Multifactor analysis of variance in the calculation of SUVs at the whole-brain and cerebral cortex levels

	Source	Sum Sq	d.f	Mean Sq	F	P value
Whole-brain level	Brain regions	29,234.7	20	1461.7	14,265.0	< 0.001
	Subjects	39,571.9	39	1014.7	9902.1	< 0.001
	Methods	857.3	7	122.5	1195.2	< 0.001
	Brain region × Subject	5103.8	780	6.54	63.9	< 0.001
	Brain region × Method	1947.4	140	13.9	135.7	< 0.001
	Subject × Method	163.6	273	0.6	5.8	< 0.001
	Error	559.5	5460	0.1
	Total	77,438.1	6719
Cerebral cortex level	Brain region	22,250.2	47	473.4	4261.8	< 0.001
	Subject	137,029.7	39	3513.6	31,630.8	< 0.001
	Method	3329.5	7	475.6	4282.0	< 0.001
	Brain region × Subject	6336.7	1833	3.5	31.1	< 0.001
	Brain region × Method	2164.6	329	6.6	59.2	< 0.001
	Subject × Method	682.8	273	2.5	22.5	< 0.001
	Error	1425.3	12,831	0.1
	Total	173,218.8	15,359

Sum Sq. sum of square; d.f. degree of freedom; Mean Sq. mean square; and F F value