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Table 1 Patient and clinical characteristics with PET/CT findings

From: A dual-tracer approach using [11C]CH and [18F]FDG in HCC clinical decision making

Sex

Age (years)

Scan delaya (days)

Underlying disorder liver

BCLC stage

Previous therapy

Degree of differentiation at histopathology

Reason for dual-tracer examination

Critical finding

18F-FDG

11C-CH

Other findings

Follow-up therapy

M

49

2

NASH

B

MWA

N/A

Suspect CT/MRI

Recurrence ablation site, mediastinal lymph node

+

Both: mHCC m. adductor longus

Palliative with chemotherapy

F

71

0

Steatosis

C

MWA, Resection

Poorly

Rise of tumour marker

Recurrence ablation site, precaval lymph node

+ 

+

CH: needle tract recurrence, prostate carcinoma

BSC

M

72

1

NASH

0

SIRT

Poorly

Suspect CT/MRI

Retrocaval lymph node

+

+

 

Immunotherapy

M

77

0

None

B

 

Poorly

Suspect CT/MRI

HCC liver right lobe and portocaval lymph node

+

+

FDG: liver lymph node

CH: HCC S1

Start systemic immunotherapy

F

64

0

NASH

B

MWA

Moderately

Suspect CT/MRI

mHCC Th6

+

+

 

Radiotherapy

F

74

3

Cirrhosis (HBV)

A

 

Moderately

Rise of tumour marker

Growth known HCC S5/6

+

 

Surgical partial liver resection

F

65

0

Cirrhosis (Alcohol)

B

 

Well

Suspect CT/MRI

Bilateral lung carcinoma

+

+

 

Surgical partial lung resection

F

75

0

Fibrosis

B

Resection

Well

Rise of tumour marker

HCC S1

+

+

 

TACE

F

39

12

None

B

 

Well

Suspect CT/MRI

Multifocal HCC liver right lobe

+

+

 

OLT

M

75

12

NASH

C

MWA

Well

Suspect CT/MRI

Needle tract recurrence after ablation

+

CH: 5th costovertebral junction

BSC

M

74

0

Cirrhosis (Alcohol)

B

TACE

N/A

Suspect CT

HCC recurrence

 

SIRT

M

66

0

NASH

A

MWA

N/A

Suspect CT/MRI

Lymph node lesser omentum and a. hepatica communis

+

FDG: mHCC ablation site S4/5

BSC

M

67

0

Cirrhosis (Alcohol)

A

MWA

N/A

Rise of tumour marker

mHCC S1, HCC recurrence ablation site S2/3

+

+

FDG: tumour thrombus v. porta

Palliative with sorafenib

M

81

1

Cirrhosis (Hemochromatosis)

A

SIRT, MWA

N/A

Suspect CT/MRI

Thoracic lymph nodes

+

+

FDG: recurrence ablation site

Palliative with sorafenib

M

60

0

Cirrhosis (Alcohol)

A

 

N/A

Suspect CT/MRI

Known HCC S7/8

+

+

 

SIRT

F

76

0

Cirrhosis (Alcohol)

C

 

N/A

Suspect CT/MRI. Rise of tumour marker

Known HCC S7/8

+

+

 

SIRT

M

53

3

Cirrhosis (Alcohol)

A

MWA, Resection

N/A

Rise of tumour marker

mHCC pararectal fat

+

 

Surgical local resection

M

57

0

NASH

A

 

N/A

Rise of tumour marker

mHCC liver subcapsular S8

+

 

MWA

F

62

18

Cirrhosis (Alcohol)

0

MWA

N/A

Rise of tumour marker

HCC S7/8

+

 

MWA

  1. aDays between patient receiving one and the other PET/CT scan
  2. M male, F female, NASH non-alcoholic steatohepatitis, HBV hepatitis B-virus, BCLC Barcelona clinic liver cancer, MWA microwave ablation, SIRT selective internal radiation therapy, TACE trans-arterial chemoembolization, N/A not available, BSC best supportive care, OLT orthotopic liver transplantation