Characterisation of a novel [18F]FDG brain PET database and combination with a second database for optimising detection of focal abnormalities, using focal cortical dysplasia as an example

EJNMMI Research

Table 3 Detection of FCD-related decreased [¹⁸F]FDG uptake in patients

	Marseille	MRXFDG	Both DB (2STT)	Both DB (FF—under 60 years)	Both DB (FF—all ages, linear age covariate)	Both DB (FF—all ages, quadratic age covariate)
Datasets in database(s) used	54	37	91	70	91	91
Lesions found (any p value)
n	17	18	14	24	22	19
%	50	53	41	71	65	56
Lesions found (significant p value)
n	14	18	12	22	19	18
%	41	53	41	65	56	53

Summary of detection of FCD-related decreased uptake in n = 34 patients, using any initial threshold (see text for details)
DB = database, 2STT = two-sided t test, FF = full factorial model
Best performance highlighted in bold
Initial voxel thresholds used were p < 0.001 and p < 0.01
Clusters were considered significant when their cluster p value was < 0.05