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Table 1 Absorbed doses (mGy/MBq) to organs and effective dose (mSv/MBq) per administered activity for i.v. administered hDSC and rMac labelled with [89Zr]Zr-(oxinate)4 or [89Zr]Zr-DFO-NCS in rats

From: Comparative in vivo biodistribution of cells labelled with [89Zr]Zr-(oxinate)4 or [89Zr]Zr-DFO-NCS using PET

Dosimetry: absorbed dose and effective dose from radiolabelled cells

Organ

hDSC

rMac

[89Zr]Zr-(oxinate)4

[89Zr]Zr-DFO-NCS

[89Zr]Zr-(oxinate)4

[89Zr]Zr-DFO-NCS

Lungs

p value

1.28 [0.43–2.62]

2.72 [1.40–4.39]

0.94 [0.71–1.23]

1.86 [0.80–3.0]

0.18

0.23

Liver

p value

1.18 [1.11–1.35]

0.43 [0.39–0.50]

0.86 [0.51–1.39]

0.60 [0.49–0.78]

** < 0.001

0.41

Spleen

p value

1.38 [1.15–1.64]

0.53 [0.44–0.65]

1.37 [1.11–1.83]

0.83 [0.66–1.16]

**0.002

0.13

Kidneys

p value

0.50 [0033.-0.71]

0.32 [0.22–0.39]

0.42 [0.30–0.56]

0.41 [0.39–0.44]

0.15

0.78

Bone marrow

p value

0.25 [0.12–0.37]

0.27 [0.17–0.40]

0.22 [0.22–0.23]

0.21 [0.14–0.30]

0.81

0.82

Effective dose

p value

0.24 [0.13–0.35]

0.35 [0.23–0.52]

0.17 [0.13–0.20]

0.33 [0.24–0.46]

0.27

0.08

  1. Values correspond to the arithmetic mean [range] of projected human doses. A statistically significant difference between [89Zr]Zr-(oxinate)4 and [89Zr]Zr-DFO-NCS for the same cell type is marked as **for p ≤ 0.01. A p-value of ≤ 0.05 was considered statistically significant