EJNMMI Research

Table 1 The table of optimization for step 2 from [¹⁸F]15 to [¹⁸F]1

From: Synthesis and preclinical evaluation of a novel fluorine-18 labeled small-molecule PET radiotracer for imaging of CXCR3 receptor in mouse models of atherosclerosis

Entry	Solvent	Additive	Temp	RCC (%)^a
1	MeOH	HOAc	50	< 3
2	MeOH	None	50	–
3	DMF	HOAc	50	5 ± 3
4	DMF	HOAc	110	12 ± 5
5	DMF	None	110	< 5
6	DMSO	None	110	11 ± 5
7	DMSO	HOAc	110	36 ± 4

Conditions: [¹⁸F]15 (740–2220 MBq), 9 (5 ± 0.5 mg), NaBH₃CN (11 ± 1 mg), HOAc (10 μL), 20 min
^aBased on radio-TLC (0.1% Et₃N, 10% MeOH in DCM, R_f 0.3)

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