EJNMMI Research

Table 3 Mice-to-human extrapolation for [⁶⁴Cu]Cu-1C1m-Fc 3 DOTA

From: From bench to bedside: ⁶⁴Cu/¹⁷⁷Lu 1C1m-Fc anti TEM-1: mice-to-human dosimetry extrapolations for future theranostic applications

[⁶⁴Cu]Cu-1C1m-Fc 3 DOTA	TIAC (MBq.h/MBq)
[⁶⁴Cu]Cu-1C1m-Fc 3 DOTA	M1		M2		M3		M4
Source organs	M	F	M	F	M	F	M	F
Left colon	0.091	0.090	0.055	0.067	0.073	0.072	0.048	0.058
Small intestine	0.434	0.434	0.181	0.194	0.296	0.296	0.124	0.132
Stomach cont	0.096	0.096	0.084	0.094	0.077	0.077	0.067	0.075
Right colon	0.122	0.122	0.073	0.090	0.098	0.098	0.064	0.079
Rectum	0.059	0.060	0.035	0.044	0.047	0.048	0.031	0.039
Heart cont	0.513	0.508	0.146	0.128	2.645	2.645	0.754	0.665
Heart wall	0.187	0.187	0.151	0.139	0.175	0.175	0.141	0.130
Kidneys	0.585	0.585	0.165	0.178	0.645	0.645	0.182	0.196
Liver	2.689	2.689	1.164	1.101	2.429	2.429	1.051	0.995
Lungs	0.338	0.338	0.684	0.658	0.415	0.415	0.840	0.809
Ovaries		0.056		0.005		0.050		0.005
Red marrow	1.176	1.236	1.176	1.236	1.853	1.947	1.853	1.947
Spleen	0.194	0.194	0.087	0.092	0.209	0.209	0.093	0.098
Uterus		0.088		0.024		0.176		0.047
Total body	13.7	13.7	13.7	13.7	13.7	13.7	13.7	13.7
Rest of body	7.3	7.1	9.7	9.7	4.8	4.5	8.5	8.5

[⁶⁴Cu]Cu-1C1m-Fc 3 DOTA mice-to-human extrapolation of average source organ TIACs was obtained with the four considered dosimetry methods (M1-M4) for both the adult male (M) and female (F) human subjects

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