EJNMMI Research

Table 2 Mice-to-human extrapolated dosimetry for [¹⁷⁷Lu]Lu-1C1m-Fc 3 DOTA

From: From bench to bedside: ⁶⁴Cu/¹⁷⁷Lu 1C1m-Fc anti TEM-1: mice-to-human dosimetry extrapolations for future theranostic applications

[¹⁷⁷Lu]Lu-1C1m-Fc 3 DOTA	TIAC (MBq.h/MBq)
[¹⁷⁷Lu]Lu-1C1m-Fc 3 DOTA	M1		M2		M3		M4
Source organs	M	F	M	F	M	F	M	F
Left colon	0.609	0.600	0.130	0.158	0.985	0.970	0.210	0.255
Small intestine	2.842	2.842	0.570	0.755	4.521	4.521	0.906	0.970
Stomach cont	0.575	0.575	0.636	0.716	0.553	0.570	0.612	0.710
Right colon	0.651	0.687	0.139	0.181	1.313	1.315	0.280	0.346
Rectum	0.113	0.141	0.201	0.223	0.635	0.647	0.135	0.170
Heart cont	1.083	1.083	0.764	0.835	2.841	2.815	2.003	1.752
Heart wall	0.343	0.343	0.157	0.179	0.891	0.891	0.407	0.375
Kidneys	2.129	2.129	0.553	0.597	4.226	4.226	1.098	1.185
Liver	31.678	31.678	12.321	11.659	31.678	31.678	12.321	11.659
Lungs	0.744	0.744	1.646	1.964	1.894	1.894	4.191	4.037
Ovaries		0.241		0.013		0.448		0.024
Red marrow	2.508	2.635	2.508	2.635	6.517	6.847	6.517	6.847
Spleen	1.163	1.163	0.536	0.565	1.163	1.163	0.536	0.565
UB	0.140	0.140	0.140	0.140	0.140	0.140	0.140	0.140
Uterus		1.727		0.581		0.581		0.581
Total body	98.8	98.8	98.8	98.8	98.8	98.8	98.8	98.8
Rest of body	54.2	52.1	78.5	77.6	41.4	40.1	69.4	69.2

[¹⁷⁷Lu]Lu-1C1m-Fc 3 DOTA mice-to-human extrapolation of average source organ TIACs was obtained with the four considered dosimetry methods (M1-M4) for both the adult male (M) and female (F) human subjects

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