EJNMMI Research

Table 1 Mice-to-human extrapolated dosimetry for [¹⁷⁷Lu]Lu-1C1m-Fc 1 DOTA

From: From bench to bedside: ⁶⁴Cu/¹⁷⁷Lu 1C1m-Fc anti TEM-1: mice-to-human dosimetry extrapolations for future theranostic applications

[¹⁷⁷Lu]Lu-1C1m-Fc 1 DOTA	TIAC (MBq.h/MBq)
[¹⁷⁷Lu]Lu-1C1m-Fc 1 DOTA	M1		M2		M3		M4
Source organs	M	F	M	F	M	F	M	F
Left colon	0.708	0.697	0.154	0.188	1.134	1.118	0.247	0.301
Small intestine	3.548	3.548	0.747	0.800	5.499	5.499	1.158	1.240
Stomach cont	0.824	0.824	0.324	0.365	0.824	0.824	0.324	0.365
Right colon	0.944	0.945	0.205	0.254	1.513	1.515	0.329	0.407
Rectum	0.456	0.465	0.099	0.125	0.731	0.745	0.159	0.200
Heart cont	1.961	1.961	2.436	2.150	5.364	5.364	3.455	3.050
Heart wall	0.509	0.509	0.402	0.371	1.066	1.066	0.843	0.777
Kidneys	3.592	3.592	0.919	0.992	4.928	4.928	1.261	1.361
Liver	22.894	22.894	9.183	8.690	22.401	22.401	8.985	8.503
Lungs	1.101	1.101	2.166	2.087	2.507	2.507	4.931	4.749
Ovaries		0.468		0.036		0.598		0.049
Salivary glands	0.800	0.852	0.161	0.161	0.800	0.852	0.161	0.172
Red marrow	2.211	2.475	5.588	5.230	2.922	3.070	7.386	6.912
Spleen	1.132	1.132	0.454	0.478	1.476	1.476	0.591	0.623
UB	0.186	0.199	0.677	0.624	0.186	0.199	0.677	0.665
Uterus		2.886		0.620		2.886		0.661
Total body	111.1	111.1	111.1	111.1	111.1	111.1	111.1	111.1
Rest of body	70.2	66.5	87.6	87.9	59.7	56.0	80.6	81.0

[¹⁷⁷Lu]Lu-1C1m-Fc 1 DOTA mice-to-human extrapolation of average source organ TIACs was obtained with the four considered dosimetry methods (M1-M4) for both the adult male (M) and female (F) human subjects

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