EJNMMI Research

Table 2 Sensitivity analysis results for the salivary glands, kidney and tumor compartments with area under the concentration–time curve (0–24 h) as the output parameter

From: Predicting the effect of different folate doses on [⁶⁸Ga]Ga-PSMA-11 organ and tumor uptake using physiologically based pharmacokinetic modeling

Compartment	Input parameter	Sensitivity value
Salivary glands	[⁶⁸Ga]Ga-PSMA-11 dose (µg)	0.935
Salivary glands	Salivary glands volume	− 0.901
Salivary glands	PSMA amount salivary glands	0.891
Salivary glands	K_D	− 0.620
Salivary glands	Plasma protein scale factor	0.550
Salivary glands	Fraction unbound	0.550
Kidney	[⁶⁸Ga]Ga-PSMA-11 dose (µg)	0.975
Kidney	Kidney volume	− 0.972
Kidney	PSMA amount kidney	0.693
Kidney	K_D	− 0.519
Tumor	[⁶⁸Ga]Ga-PSMA-11 dose (µg)	1.01
Tumor	Tumor blood flow	0.971

Only sensitivity values < − 0.5 or > 0.5 were reported
K_D, equilibrium dissociation constant; PSMA, prostate-specific membrane antigen

Back to article page